An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides

An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)(2)-catalyzed cascade cyclization of easily prepared ortho–propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and to...

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Detalles Bibliográficos
Autores principales: Yang, Tao, Song, Xian-Rong, Yang, Ruchun, Ding, Haixin, Bai, Jiang, Xiao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803861/
https://www.ncbi.nlm.nih.gov/pubmed/31569519
http://dx.doi.org/10.3390/molecules24193526
Descripción
Sumario:An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)(2)-catalyzed cascade cyclization of easily prepared ortho–propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates.

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