An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides

An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)(2)-catalyzed cascade cyclization of easily prepared ortho–propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and to...

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Detalles Bibliográficos
Autores principales: Yang, Tao, Song, Xian-Rong, Yang, Ruchun, Ding, Haixin, Bai, Jiang, Xiao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803861/
https://www.ncbi.nlm.nih.gov/pubmed/31569519
http://dx.doi.org/10.3390/molecules24193526
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author Yang, Tao
Song, Xian-Rong
Yang, Ruchun
Ding, Haixin
Bai, Jiang
Xiao, Qiang
author_facet Yang, Tao
Song, Xian-Rong
Yang, Ruchun
Ding, Haixin
Bai, Jiang
Xiao, Qiang
author_sort Yang, Tao
collection PubMed
description An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)(2)-catalyzed cascade cyclization of easily prepared ortho–propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates.
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spelling pubmed-68038612019-11-18 An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides Yang, Tao Song, Xian-Rong Yang, Ruchun Ding, Haixin Bai, Jiang Xiao, Qiang Molecules Communication An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)(2)-catalyzed cascade cyclization of easily prepared ortho–propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates. MDPI 2019-09-29 /pmc/articles/PMC6803861/ /pubmed/31569519 http://dx.doi.org/10.3390/molecules24193526 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Yang, Tao
Song, Xian-Rong
Yang, Ruchun
Ding, Haixin
Bai, Jiang
Xiao, Qiang
An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides
title An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides
title_full An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides
title_fullStr An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides
title_full_unstemmed An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides
title_short An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides
title_sort efficient approach to phosphorylated isoindoline fused with triazoles via zn-catalyzed cascade cyclization of 2–propynol benzyl azides and diarylphosphine oxides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803861/
https://www.ncbi.nlm.nih.gov/pubmed/31569519
http://dx.doi.org/10.3390/molecules24193526
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