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Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver

A novel compound consisting of a zirconium phosphate-glycinediphosphonate (ZPGly) has recently been introduced. This 2D-structured material forming nanosheets was exfoliated under appropriate conditions, producing colloidal aqueous dispersions (ZPGly-e) which were then loaded with zinc (Zn/ZPGly) or...

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Autores principales: Campoccia, Davide, Ravaioli, Stefano, Vivani, Riccardo, Donnadio, Anna, Vischini, Eleonora, Russo, Alessandro, Visai, Livia, Arciola, Carla Renata, Montanaro, Lucio, Nocchetti, Morena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804034/
https://www.ncbi.nlm.nih.gov/pubmed/31569362
http://dx.doi.org/10.3390/ma12193184
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author Campoccia, Davide
Ravaioli, Stefano
Vivani, Riccardo
Donnadio, Anna
Vischini, Eleonora
Russo, Alessandro
Visai, Livia
Arciola, Carla Renata
Montanaro, Lucio
Nocchetti, Morena
author_facet Campoccia, Davide
Ravaioli, Stefano
Vivani, Riccardo
Donnadio, Anna
Vischini, Eleonora
Russo, Alessandro
Visai, Livia
Arciola, Carla Renata
Montanaro, Lucio
Nocchetti, Morena
author_sort Campoccia, Davide
collection PubMed
description A novel compound consisting of a zirconium phosphate-glycinediphosphonate (ZPGly) has recently been introduced. This 2D-structured material forming nanosheets was exfoliated under appropriate conditions, producing colloidal aqueous dispersions (ZPGly-e) which were then loaded with zinc (Zn/ZPGly) or silver ions. Silver ions were subsequently reduced to produce metallic silver nanoparticles on exfoliated ZPGly nanosheets (Ag@ZPGly). In the search for new anti-infective materials, the present study investigated the properties of colloidal dispersions of ZPGly-e, Zn/ZPGly, and Ag@ZPGly. Ag@ZPGly was found to be a bactericidal material and was assayed to define its minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) on the five most prevalent pathogens of orthopaedic implant infections, namely: Staphylococcus aureus ATCC25923, Staphylococcus epidermidis RP62A, Enterococcus faecalis ATCC29212, Escherichia coli ATCC51739, and Pseudomonas aeruginosa ATCC27853. MIC and MBC were in the range of 125–250 μg/mL and 125–1000 μg/mL, respectively, with E. coli being the most sensitive species. Even colloidal suspensions of exfoliated ZPGly nanosheets and Zn/ZPGly exhibited some intrinsic antibacterial properties, but only at greater concentrations. Unexpectedly, Zn/ZPGly was less active than ZPGly-e.
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spelling pubmed-68040342019-11-18 Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver Campoccia, Davide Ravaioli, Stefano Vivani, Riccardo Donnadio, Anna Vischini, Eleonora Russo, Alessandro Visai, Livia Arciola, Carla Renata Montanaro, Lucio Nocchetti, Morena Materials (Basel) Article A novel compound consisting of a zirconium phosphate-glycinediphosphonate (ZPGly) has recently been introduced. This 2D-structured material forming nanosheets was exfoliated under appropriate conditions, producing colloidal aqueous dispersions (ZPGly-e) which were then loaded with zinc (Zn/ZPGly) or silver ions. Silver ions were subsequently reduced to produce metallic silver nanoparticles on exfoliated ZPGly nanosheets (Ag@ZPGly). In the search for new anti-infective materials, the present study investigated the properties of colloidal dispersions of ZPGly-e, Zn/ZPGly, and Ag@ZPGly. Ag@ZPGly was found to be a bactericidal material and was assayed to define its minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) on the five most prevalent pathogens of orthopaedic implant infections, namely: Staphylococcus aureus ATCC25923, Staphylococcus epidermidis RP62A, Enterococcus faecalis ATCC29212, Escherichia coli ATCC51739, and Pseudomonas aeruginosa ATCC27853. MIC and MBC were in the range of 125–250 μg/mL and 125–1000 μg/mL, respectively, with E. coli being the most sensitive species. Even colloidal suspensions of exfoliated ZPGly nanosheets and Zn/ZPGly exhibited some intrinsic antibacterial properties, but only at greater concentrations. Unexpectedly, Zn/ZPGly was less active than ZPGly-e. MDPI 2019-09-28 /pmc/articles/PMC6804034/ /pubmed/31569362 http://dx.doi.org/10.3390/ma12193184 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campoccia, Davide
Ravaioli, Stefano
Vivani, Riccardo
Donnadio, Anna
Vischini, Eleonora
Russo, Alessandro
Visai, Livia
Arciola, Carla Renata
Montanaro, Lucio
Nocchetti, Morena
Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
title Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
title_full Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
title_fullStr Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
title_full_unstemmed Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
title_short Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver
title_sort antibacterial properties of a novel zirconium phosphate-glycinediphosphonate loaded with either zinc or silver
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804034/
https://www.ncbi.nlm.nih.gov/pubmed/31569362
http://dx.doi.org/10.3390/ma12193184
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