Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a s...

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Detalles Bibliográficos
Autores principales: Khandazhinskaya, Anastasia L., Matyugina, Elena S., Solyev, Pavel N., Wilkinson, Maggie, Buckheit, Karen W., Buckheit, Robert W., Chernousova, Larisa N., Smirnova, Tatiana G., Andreevskaya, Sofya N., Alzahrani, Khalid J., Natto, Manal J., Kochetkov, Sergey N., de Koning, Harry P., Seley-Radtke, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804079/
https://www.ncbi.nlm.nih.gov/pubmed/31546633
http://dx.doi.org/10.3390/molecules24193433
Descripción
Sumario:Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

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