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Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a s...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804079/ https://www.ncbi.nlm.nih.gov/pubmed/31546633 http://dx.doi.org/10.3390/molecules24193433 |
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| author | Khandazhinskaya, Anastasia L. Matyugina, Elena S. Solyev, Pavel N. Wilkinson, Maggie Buckheit, Karen W. Buckheit, Robert W. Chernousova, Larisa N. Smirnova, Tatiana G. Andreevskaya, Sofya N. Alzahrani, Khalid J. Natto, Manal J. Kochetkov, Sergey N. de Koning, Harry P. Seley-Radtke, Katherine L. |
| author_facet | Khandazhinskaya, Anastasia L. Matyugina, Elena S. Solyev, Pavel N. Wilkinson, Maggie Buckheit, Karen W. Buckheit, Robert W. Chernousova, Larisa N. Smirnova, Tatiana G. Andreevskaya, Sofya N. Alzahrani, Khalid J. Natto, Manal J. Kochetkov, Sergey N. de Koning, Harry P. Seley-Radtke, Katherine L. |
| author_sort | Khandazhinskaya, Anastasia L. |
| collection | PubMed |
| description | Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein. |
| format | Online Article Text |
| id | pubmed-6804079 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68040792019-11-18 Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents Khandazhinskaya, Anastasia L. Matyugina, Elena S. Solyev, Pavel N. Wilkinson, Maggie Buckheit, Karen W. Buckheit, Robert W. Chernousova, Larisa N. Smirnova, Tatiana G. Andreevskaya, Sofya N. Alzahrani, Khalid J. Natto, Manal J. Kochetkov, Sergey N. de Koning, Harry P. Seley-Radtke, Katherine L. Molecules Article Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein. MDPI 2019-09-21 /pmc/articles/PMC6804079/ /pubmed/31546633 http://dx.doi.org/10.3390/molecules24193433 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Khandazhinskaya, Anastasia L. Matyugina, Elena S. Solyev, Pavel N. Wilkinson, Maggie Buckheit, Karen W. Buckheit, Robert W. Chernousova, Larisa N. Smirnova, Tatiana G. Andreevskaya, Sofya N. Alzahrani, Khalid J. Natto, Manal J. Kochetkov, Sergey N. de Koning, Harry P. Seley-Radtke, Katherine L. Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents |
| title | Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents |
| title_full | Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents |
| title_fullStr | Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents |
| title_full_unstemmed | Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents |
| title_short | Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents |
| title_sort | investigation of 5’-norcarbocyclic nucleoside analogues as antiprotozoal and antibacterial agents |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804079/ https://www.ncbi.nlm.nih.gov/pubmed/31546633 http://dx.doi.org/10.3390/molecules24193433 |
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