Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems

Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass...

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Autores principales: Huang, Sheng Zhuo, Duan, Lin Ping, Wang, Hao, Mei, Wen Li, Dai, Hao Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804138/
https://www.ncbi.nlm.nih.gov/pubmed/31597363
http://dx.doi.org/10.3390/molecules24193628
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author Huang, Sheng Zhuo
Duan, Lin Ping
Wang, Hao
Mei, Wen Li
Dai, Hao Fu
author_facet Huang, Sheng Zhuo
Duan, Lin Ping
Wang, Hao
Mei, Wen Li
Dai, Hao Fu
author_sort Huang, Sheng Zhuo
collection PubMed
description Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman’s Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.
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spelling pubmed-68041382019-11-18 Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems Huang, Sheng Zhuo Duan, Lin Ping Wang, Hao Mei, Wen Li Dai, Hao Fu Molecules Article Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman’s Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively. MDPI 2019-10-08 /pmc/articles/PMC6804138/ /pubmed/31597363 http://dx.doi.org/10.3390/molecules24193628 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Sheng Zhuo
Duan, Lin Ping
Wang, Hao
Mei, Wen Li
Dai, Hao Fu
Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
title Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
title_full Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
title_fullStr Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
title_full_unstemmed Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
title_short Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
title_sort two new ache inhibitors isolated from li folk herb heilaohu “kadsura coccinea” stems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804138/
https://www.ncbi.nlm.nih.gov/pubmed/31597363
http://dx.doi.org/10.3390/molecules24193628
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