Characterization of Eight Novel Spiroleptosphols from Fusarium avenaceum

Chemical analyses of Fusarium avenaceum grown on banana medium resulted in eight novel spiroleptosphols, T1, T2 and U–Z (1–8). The structures were elucidated by a combination of high-resolution mass spectrometric data and 1- and 2-D NMR experiments. The relative stereochemistry was assigned by (1)H...

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Detalles Bibliográficos
Autores principales: Westphal, Klaus Ringsborg, Werner, Manuela Ilse Helga, Nielsen, Katrine Amalie Hamborg, Sørensen, Jens Laurids, Andrushchenko, Valery, Winde, Jacob, Hertz, Morten, Jensen, Mikkel Astrup, Mortensen, Mathilde Lauge, Bouř, Petr, Sondergaard, Teis Esben, Wimmer, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804164/
https://www.ncbi.nlm.nih.gov/pubmed/31561557
http://dx.doi.org/10.3390/molecules24193498
Descripción
Sumario:Chemical analyses of Fusarium avenaceum grown on banana medium resulted in eight novel spiroleptosphols, T1, T2 and U–Z (1–8). The structures were elucidated by a combination of high-resolution mass spectrometric data and 1- and 2-D NMR experiments. The relative stereochemistry was assigned by (1)H coupling and NOESY/ROESY experiments. Absolute stereochemistry established for 7 by vibrational circular dichroism was found analogous to that of the putative polyketide spiroleptosphol from Leptosphaeria doliolum.

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