Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway

[Image: see text] The Fanconi anemia pathway orchestrates the repair of DNA interstrand cross-links and stalled replication forks. A key step in this pathway is UBE2T and FANCL-dependent monoubiquitylation of the FANCD2-FANCI complex. The Fanconi anemia pathway represents an attractive therapeutic t...

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Detalles Bibliográficos
Autores principales: Cornwell, Matthew J., Thomson, Graeme J., Coates, Julia, Belotserkovskaya, Rimma, Waddell, Ian D., Jackson, Stephen P., Galanty, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804243/
https://www.ncbi.nlm.nih.gov/pubmed/31525021
http://dx.doi.org/10.1021/acschembio.9b00570

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