Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces

[Image: see text] Protein–protein interactions (PPIs) are vital to all biological processes. These interactions are often dynamic, sometimes transient, typically occur over large topographically shallow protein surfaces, and can exhibit a broad range of affinities. Considerable progress has been mad...

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Detalles Bibliográficos
Autores principales: Ibarra, Amaurys A., Bartlett, Gail J., Hegedüs, Zsöfia, Dutt, Som, Hobor, Fruzsina, Horner, Katherine A., Hetherington, Kristina, Spence, Kirstin, Nelson, Adam, Edwards, Thomas A., Woolfson, Derek N., Sessions, Richard B., Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804253/
https://www.ncbi.nlm.nih.gov/pubmed/31525028
http://dx.doi.org/10.1021/acschembio.9b00560

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