Long-term management of high-grade atrioventricular block using cilostazol in a cat

CASE SUMMARY: A 12-year-old neutered female domestic shorthair cat was admitted for syncope. Clinical signs and electrocardiography revealed high-grade atrioventricular (AV) block. Treatment with cilostazol ameliorated the clinical signs and arrhythmia. However, the high-grade AV block recurred on s...

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Autores principales: Iwasa, Naoki, Nishii, Naohito, Takashima, Satoshi, Kobatake, Yui, Nomura, Saki, Iwasa, Kazuko, Iwasa, Tatsuo, Suzuki, Tomomi, Machida, Noboru, Kitagawa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804363/
https://www.ncbi.nlm.nih.gov/pubmed/31673397
http://dx.doi.org/10.1177/2055116919878913
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author Iwasa, Naoki
Nishii, Naohito
Takashima, Satoshi
Kobatake, Yui
Nomura, Saki
Iwasa, Kazuko
Iwasa, Tatsuo
Suzuki, Tomomi
Machida, Noboru
Kitagawa, Hitoshi
author_facet Iwasa, Naoki
Nishii, Naohito
Takashima, Satoshi
Kobatake, Yui
Nomura, Saki
Iwasa, Kazuko
Iwasa, Tatsuo
Suzuki, Tomomi
Machida, Noboru
Kitagawa, Hitoshi
author_sort Iwasa, Naoki
collection PubMed
description CASE SUMMARY: A 12-year-old neutered female domestic shorthair cat was admitted for syncope. Clinical signs and electrocardiography revealed high-grade atrioventricular (AV) block. Treatment with cilostazol ameliorated the clinical signs and arrhythmia. However, the high-grade AV block recurred on several occasions. After 640 days, the cat presented again with clinical deterioration owing to reoccurrence of the arrhythmia and it died 11 days later. Histopathological examination revealed a loss of conduction cells within the His bundle. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is the first report of high-grade AV block treated with cilostazol in a cat. Treatment with cilostazol prolonged survival for 650 days without pacemaker implantation. Histological findings suggested that the AV block was related to fibrosis of the impulse conduction system.
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spelling pubmed-68043632019-10-31 Long-term management of high-grade atrioventricular block using cilostazol in a cat Iwasa, Naoki Nishii, Naohito Takashima, Satoshi Kobatake, Yui Nomura, Saki Iwasa, Kazuko Iwasa, Tatsuo Suzuki, Tomomi Machida, Noboru Kitagawa, Hitoshi JFMS Open Rep Case Report CASE SUMMARY: A 12-year-old neutered female domestic shorthair cat was admitted for syncope. Clinical signs and electrocardiography revealed high-grade atrioventricular (AV) block. Treatment with cilostazol ameliorated the clinical signs and arrhythmia. However, the high-grade AV block recurred on several occasions. After 640 days, the cat presented again with clinical deterioration owing to reoccurrence of the arrhythmia and it died 11 days later. Histopathological examination revealed a loss of conduction cells within the His bundle. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is the first report of high-grade AV block treated with cilostazol in a cat. Treatment with cilostazol prolonged survival for 650 days without pacemaker implantation. Histological findings suggested that the AV block was related to fibrosis of the impulse conduction system. SAGE Publications 2019-10-20 /pmc/articles/PMC6804363/ /pubmed/31673397 http://dx.doi.org/10.1177/2055116919878913 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Iwasa, Naoki
Nishii, Naohito
Takashima, Satoshi
Kobatake, Yui
Nomura, Saki
Iwasa, Kazuko
Iwasa, Tatsuo
Suzuki, Tomomi
Machida, Noboru
Kitagawa, Hitoshi
Long-term management of high-grade atrioventricular block using cilostazol in a cat
title Long-term management of high-grade atrioventricular block using cilostazol in a cat
title_full Long-term management of high-grade atrioventricular block using cilostazol in a cat
title_fullStr Long-term management of high-grade atrioventricular block using cilostazol in a cat
title_full_unstemmed Long-term management of high-grade atrioventricular block using cilostazol in a cat
title_short Long-term management of high-grade atrioventricular block using cilostazol in a cat
title_sort long-term management of high-grade atrioventricular block using cilostazol in a cat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804363/
https://www.ncbi.nlm.nih.gov/pubmed/31673397
http://dx.doi.org/10.1177/2055116919878913
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