The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer

The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Xiaoming, Chen, Bin, Liu, Min, Yang, Zhiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804436/
https://www.ncbi.nlm.nih.gov/pubmed/31650020
http://dx.doi.org/10.1016/j.omto.2019.08.007
Descripción
Sumario:The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms.

Ejemplares similares