The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer

The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of...

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Detalles Bibliográficos
Autores principales: Zhong, Xiaoming, Chen, Bin, Liu, Min, Yang, Zhiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804436/
https://www.ncbi.nlm.nih.gov/pubmed/31650020
http://dx.doi.org/10.1016/j.omto.2019.08.007
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author Zhong, Xiaoming
Chen, Bin
Liu, Min
Yang, Zhiwen
author_facet Zhong, Xiaoming
Chen, Bin
Liu, Min
Yang, Zhiwen
author_sort Zhong, Xiaoming
collection PubMed
description The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms.
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spelling pubmed-68044362019-10-24 The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer Zhong, Xiaoming Chen, Bin Liu, Min Yang, Zhiwen Mol Ther Oncolytics Article The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms. American Society of Gene & Cell Therapy 2019-08-30 /pmc/articles/PMC6804436/ /pubmed/31650020 http://dx.doi.org/10.1016/j.omto.2019.08.007 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhong, Xiaoming
Chen, Bin
Liu, Min
Yang, Zhiwen
The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
title The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
title_full The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
title_fullStr The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
title_full_unstemmed The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
title_short The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer
title_sort role of adaptor protein card9 in colitis-associated cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804436/
https://www.ncbi.nlm.nih.gov/pubmed/31650020
http://dx.doi.org/10.1016/j.omto.2019.08.007
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