Cargando…
Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial
Fatigue is often one of the most commonly reported symptoms in prostate cancer survivors, but it is also one of the least understood cancer-related symptoms. Fatigue is associated with psychological distress, disruptions in sleep quality, and impairments in health-related quality of life. Moreover,...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804681/ https://www.ncbi.nlm.nih.gov/pubmed/31650067 http://dx.doi.org/10.1016/j.conctc.2019.100431 |
_version_ | 1783461249531510784 |
---|---|
author | Kinney, Anita Y. Blair, Cindy K. Guest, Dolores D. Ani, Julianne K. Harding, Elizabeth M. Amorim, Fabiano Boyce, Tawny Rodman, Joseph Ford, C. Graham Schwartz, Matthew Rosenberg, Larissa Foran, Olivia Gardner, Jerry Lin, Yong Arap, Wadih Irwin, Michael R. |
author_facet | Kinney, Anita Y. Blair, Cindy K. Guest, Dolores D. Ani, Julianne K. Harding, Elizabeth M. Amorim, Fabiano Boyce, Tawny Rodman, Joseph Ford, C. Graham Schwartz, Matthew Rosenberg, Larissa Foran, Olivia Gardner, Jerry Lin, Yong Arap, Wadih Irwin, Michael R. |
author_sort | Kinney, Anita Y. |
collection | PubMed |
description | Fatigue is often one of the most commonly reported symptoms in prostate cancer survivors, but it is also one of the least understood cancer-related symptoms. Fatigue is associated with psychological distress, disruptions in sleep quality, and impairments in health-related quality of life. Moreover, inflammatory processes and changes related to the hypothalamic-pituitary-adrenal (HPA) axis and/or autonomic nervous system may also play a role in cancer-related fatigue. Thus, effective treatments for fatigue in prostate cancer survivors represent a current unmet need. Prior research has shown that Tai Chi Qigong, a mind-body exercise intervention, can improve physical and emotional health. Herein, we describe the protocol of the ongoing 3-arm randomized controlled Health Empowerment & Recovery Outcomes (HERO) clincal trial. One hundred sixty-six prostate cancer survivors with fatigue are randomized to a modified Tai Chi Qigong intervention (TCQ), intensity-matched body training intervention (BT), or usual care (UC) condition. Guided by biopsychosocial and psychoneuroimmunology models, we propose that TCQ, as compared to BT or UC will: i) reduce fatigue (primary outcome) in prostate cancer survivors; ii) reduce inflammation; and iii) regulate the expression of genes from two major functional clusters: a) inflammation, vasodilation and metabolite sensing and b) energy and adrenergic activation. Assessments are conducted at baseline, the 6-week midpoint of the intervention, and 1 week, 3 months, and 12 months post-intervention. If our findings show that TCQ promotes recovery from prostate cancer and its treatment, this type of intervention can be integrated into survivorship care plans as the standard of care. The study's findings will also provide novel information about underlying biobehavioral mechanisms of cancer-related fatigue. TRIAL REGISTRATION NUMBER: NCT03326713; clinicaltrials.gov. |
format | Online Article Text |
id | pubmed-6804681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68046812019-10-24 Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial Kinney, Anita Y. Blair, Cindy K. Guest, Dolores D. Ani, Julianne K. Harding, Elizabeth M. Amorim, Fabiano Boyce, Tawny Rodman, Joseph Ford, C. Graham Schwartz, Matthew Rosenberg, Larissa Foran, Olivia Gardner, Jerry Lin, Yong Arap, Wadih Irwin, Michael R. Contemp Clin Trials Commun Article Fatigue is often one of the most commonly reported symptoms in prostate cancer survivors, but it is also one of the least understood cancer-related symptoms. Fatigue is associated with psychological distress, disruptions in sleep quality, and impairments in health-related quality of life. Moreover, inflammatory processes and changes related to the hypothalamic-pituitary-adrenal (HPA) axis and/or autonomic nervous system may also play a role in cancer-related fatigue. Thus, effective treatments for fatigue in prostate cancer survivors represent a current unmet need. Prior research has shown that Tai Chi Qigong, a mind-body exercise intervention, can improve physical and emotional health. Herein, we describe the protocol of the ongoing 3-arm randomized controlled Health Empowerment & Recovery Outcomes (HERO) clincal trial. One hundred sixty-six prostate cancer survivors with fatigue are randomized to a modified Tai Chi Qigong intervention (TCQ), intensity-matched body training intervention (BT), or usual care (UC) condition. Guided by biopsychosocial and psychoneuroimmunology models, we propose that TCQ, as compared to BT or UC will: i) reduce fatigue (primary outcome) in prostate cancer survivors; ii) reduce inflammation; and iii) regulate the expression of genes from two major functional clusters: a) inflammation, vasodilation and metabolite sensing and b) energy and adrenergic activation. Assessments are conducted at baseline, the 6-week midpoint of the intervention, and 1 week, 3 months, and 12 months post-intervention. If our findings show that TCQ promotes recovery from prostate cancer and its treatment, this type of intervention can be integrated into survivorship care plans as the standard of care. The study's findings will also provide novel information about underlying biobehavioral mechanisms of cancer-related fatigue. TRIAL REGISTRATION NUMBER: NCT03326713; clinicaltrials.gov. Elsevier 2019-08-21 /pmc/articles/PMC6804681/ /pubmed/31650067 http://dx.doi.org/10.1016/j.conctc.2019.100431 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kinney, Anita Y. Blair, Cindy K. Guest, Dolores D. Ani, Julianne K. Harding, Elizabeth M. Amorim, Fabiano Boyce, Tawny Rodman, Joseph Ford, C. Graham Schwartz, Matthew Rosenberg, Larissa Foran, Olivia Gardner, Jerry Lin, Yong Arap, Wadih Irwin, Michael R. Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial |
title | Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial |
title_full | Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial |
title_fullStr | Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial |
title_full_unstemmed | Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial |
title_short | Biobehavioral effects of Tai Chi Qigong in men with prostate cancer: Study design of a three-arm randomized clinical trial |
title_sort | biobehavioral effects of tai chi qigong in men with prostate cancer: study design of a three-arm randomized clinical trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804681/ https://www.ncbi.nlm.nih.gov/pubmed/31650067 http://dx.doi.org/10.1016/j.conctc.2019.100431 |
work_keys_str_mv | AT kinneyanitay biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT blaircindyk biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT guestdoloresd biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT anijuliannek biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT hardingelizabethm biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT amorimfabiano biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT boycetawny biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT rodmanjoseph biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT fordcgraham biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT schwartzmatthew biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT rosenberglarissa biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT foranolivia biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT gardnerjerry biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT linyong biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT arapwadih biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial AT irwinmichaelr biobehavioraleffectsoftaichiqigonginmenwithprostatecancerstudydesignofathreearmrandomizedclinicaltrial |