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Serendipitous Treatment of Tularemia in Pregnancy

We present a young pregnant woman who developed ulceroglandular tularaemia following a bite wound from a kitten. She grew Francisella tularensis from the ulcer. While awaiting bacterial culture results and serology for Bartonella, she was treated with azithromycin, with resolution of fever and axill...

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Detalles Bibliográficos
Autores principales: Johnsrud, Joyce J, Smith, Carolyn Rebecca, Bradsher, Robert W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804751/
https://www.ncbi.nlm.nih.gov/pubmed/31660371
http://dx.doi.org/10.1093/ofid/ofz413
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author Johnsrud, Joyce J
Smith, Carolyn Rebecca
Bradsher, Robert W
author_facet Johnsrud, Joyce J
Smith, Carolyn Rebecca
Bradsher, Robert W
author_sort Johnsrud, Joyce J
collection PubMed
description We present a young pregnant woman who developed ulceroglandular tularaemia following a bite wound from a kitten. She grew Francisella tularensis from the ulcer. While awaiting bacterial culture results and serology for Bartonella, she was treated with azithromycin, with resolution of fever and axillary tenderness. Treatment recommendations for tularemia are either gentamicin or doxycycline, both of which can be perilous to the fetus. A Centers for Disease Control and Prevention report on the macrolide susceptibility of North American isolates of this organism has been underappreciated. The unanticipated result from this patient may give another potential option for treatment of tularemia in pregnancy.
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spelling pubmed-68047512019-10-25 Serendipitous Treatment of Tularemia in Pregnancy Johnsrud, Joyce J Smith, Carolyn Rebecca Bradsher, Robert W Open Forum Infect Dis Brief Report We present a young pregnant woman who developed ulceroglandular tularaemia following a bite wound from a kitten. She grew Francisella tularensis from the ulcer. While awaiting bacterial culture results and serology for Bartonella, she was treated with azithromycin, with resolution of fever and axillary tenderness. Treatment recommendations for tularemia are either gentamicin or doxycycline, both of which can be perilous to the fetus. A Centers for Disease Control and Prevention report on the macrolide susceptibility of North American isolates of this organism has been underappreciated. The unanticipated result from this patient may give another potential option for treatment of tularemia in pregnancy. Oxford University Press 2019-09-24 /pmc/articles/PMC6804751/ /pubmed/31660371 http://dx.doi.org/10.1093/ofid/ofz413 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Johnsrud, Joyce J
Smith, Carolyn Rebecca
Bradsher, Robert W
Serendipitous Treatment of Tularemia in Pregnancy
title Serendipitous Treatment of Tularemia in Pregnancy
title_full Serendipitous Treatment of Tularemia in Pregnancy
title_fullStr Serendipitous Treatment of Tularemia in Pregnancy
title_full_unstemmed Serendipitous Treatment of Tularemia in Pregnancy
title_short Serendipitous Treatment of Tularemia in Pregnancy
title_sort serendipitous treatment of tularemia in pregnancy
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804751/
https://www.ncbi.nlm.nih.gov/pubmed/31660371
http://dx.doi.org/10.1093/ofid/ofz413
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