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Current state of melanoma diagnosis and treatment

Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated successfully with surgery alone and survival rates are high, but after metastasis survival rates drop significantly. Therefore, early and correct diagnosis is key for ensuring patients have the best possible...

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Detalles Bibliográficos
Autores principales: Davis, Lauren E., Shalin, Sara C., Tackett, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804807/
https://www.ncbi.nlm.nih.gov/pubmed/31366280
http://dx.doi.org/10.1080/15384047.2019.1640032
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author Davis, Lauren E.
Shalin, Sara C.
Tackett, Alan J.
author_facet Davis, Lauren E.
Shalin, Sara C.
Tackett, Alan J.
author_sort Davis, Lauren E.
collection PubMed
description Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated successfully with surgery alone and survival rates are high, but after metastasis survival rates drop significantly. Therefore, early and correct diagnosis is key for ensuring patients have the best possible prognosis. Melanoma misdiagnosis accounts for more pathology and dermatology malpractice claims than any cancer other than breast cancer, as an early misdiagnosis can significantly reduce a patient’s chances of survival. As far as treatment for metastatic melanoma goes, there have been several new drugs developed over the last 10 years that have greatly improved the prognosis of patients with metastatic melanoma, however, a majority of patients do not show a lasting response to these treatments. Thus, new biomarkers and drug targets are needed to improve the accuracy of melanoma diagnosis and treatment. This article will discuss the major advancements of melanoma diagnosis and treatment from antiquity to the present day.
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spelling pubmed-68048072019-10-30 Current state of melanoma diagnosis and treatment Davis, Lauren E. Shalin, Sara C. Tackett, Alan J. Cancer Biol Ther Review Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated successfully with surgery alone and survival rates are high, but after metastasis survival rates drop significantly. Therefore, early and correct diagnosis is key for ensuring patients have the best possible prognosis. Melanoma misdiagnosis accounts for more pathology and dermatology malpractice claims than any cancer other than breast cancer, as an early misdiagnosis can significantly reduce a patient’s chances of survival. As far as treatment for metastatic melanoma goes, there have been several new drugs developed over the last 10 years that have greatly improved the prognosis of patients with metastatic melanoma, however, a majority of patients do not show a lasting response to these treatments. Thus, new biomarkers and drug targets are needed to improve the accuracy of melanoma diagnosis and treatment. This article will discuss the major advancements of melanoma diagnosis and treatment from antiquity to the present day. Taylor & Francis 2019-08-01 /pmc/articles/PMC6804807/ /pubmed/31366280 http://dx.doi.org/10.1080/15384047.2019.1640032 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Davis, Lauren E.
Shalin, Sara C.
Tackett, Alan J.
Current state of melanoma diagnosis and treatment
title Current state of melanoma diagnosis and treatment
title_full Current state of melanoma diagnosis and treatment
title_fullStr Current state of melanoma diagnosis and treatment
title_full_unstemmed Current state of melanoma diagnosis and treatment
title_short Current state of melanoma diagnosis and treatment
title_sort current state of melanoma diagnosis and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804807/
https://www.ncbi.nlm.nih.gov/pubmed/31366280
http://dx.doi.org/10.1080/15384047.2019.1640032
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