First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

BACKGROUND: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid cystic carcinoma (AdCC). Therefore, the MYB protein is an ideal target to vaccinate against to aid recruitment of tumour infiltrating lymphocytes (TILs) against these tumo...

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Autores principales: Pham, Toan, Pereira, Lloyd, Roth, Sara, Galletta, Laura, Link, Emma, Akhurst, Tim, Solomon, Ben, Michael, Michael, Darcy, Phillip, Sampurno, Shienny, Heriot, Alexander, Ramsay, Robert, Desai, Jayesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804811/
https://www.ncbi.nlm.nih.gov/pubmed/31650066
http://dx.doi.org/10.1016/j.conctc.2019.100409

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