Ankylosing spondylitis: etiology, pathogenesis, and treatments

Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment h...

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Autores principales: Zhu, Wei, He, Xuxia, Cheng, Kaiyuan, Zhang, Linjie, Chen, Di, Wang, Xiao, Qiu, Guixing, Cao, Xu, Weng, Xisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804882/
https://www.ncbi.nlm.nih.gov/pubmed/31666997
http://dx.doi.org/10.1038/s41413-019-0057-8
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author Zhu, Wei
He, Xuxia
Cheng, Kaiyuan
Zhang, Linjie
Chen, Di
Wang, Xiao
Qiu, Guixing
Cao, Xu
Weng, Xisheng
author_facet Zhu, Wei
He, Xuxia
Cheng, Kaiyuan
Zhang, Linjie
Chen, Di
Wang, Xiao
Qiu, Guixing
Cao, Xu
Weng, Xisheng
author_sort Zhu, Wei
collection PubMed
description Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.
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spelling pubmed-68048822019-10-30 Ankylosing spondylitis: etiology, pathogenesis, and treatments Zhu, Wei He, Xuxia Cheng, Kaiyuan Zhang, Linjie Chen, Di Wang, Xiao Qiu, Guixing Cao, Xu Weng, Xisheng Bone Res Review Article Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. Nature Publishing Group UK 2019-08-05 /pmc/articles/PMC6804882/ /pubmed/31666997 http://dx.doi.org/10.1038/s41413-019-0057-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Zhu, Wei
He, Xuxia
Cheng, Kaiyuan
Zhang, Linjie
Chen, Di
Wang, Xiao
Qiu, Guixing
Cao, Xu
Weng, Xisheng
Ankylosing spondylitis: etiology, pathogenesis, and treatments
title Ankylosing spondylitis: etiology, pathogenesis, and treatments
title_full Ankylosing spondylitis: etiology, pathogenesis, and treatments
title_fullStr Ankylosing spondylitis: etiology, pathogenesis, and treatments
title_full_unstemmed Ankylosing spondylitis: etiology, pathogenesis, and treatments
title_short Ankylosing spondylitis: etiology, pathogenesis, and treatments
title_sort ankylosing spondylitis: etiology, pathogenesis, and treatments
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804882/
https://www.ncbi.nlm.nih.gov/pubmed/31666997
http://dx.doi.org/10.1038/s41413-019-0057-8
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