Metronidazole-induced Encephalopathy

Metronidazole is commonly used in the treatment of anaerobic infections. While neuropathy is known to be associated with metronidazole, encephalopathy has been rarely reported. We herein present a case of metronidazole-induced encephalopathy presenting as frequent falls and slurred speech. Magnetic...

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Detalles Bibliográficos
Autores principales: Phyu, Htay, Edmond, Michael B., Kobayashi, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804936/
https://www.ncbi.nlm.nih.gov/pubmed/31692663
http://dx.doi.org/10.1016/j.idcr.2019.e00639
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author Phyu, Htay
Edmond, Michael B.
Kobayashi, Takaaki
author_facet Phyu, Htay
Edmond, Michael B.
Kobayashi, Takaaki
author_sort Phyu, Htay
collection PubMed
description Metronidazole is commonly used in the treatment of anaerobic infections. While neuropathy is known to be associated with metronidazole, encephalopathy has been rarely reported. We herein present a case of metronidazole-induced encephalopathy presenting as frequent falls and slurred speech. Magnetic resonance imaging of the brain demonstrated T2/FLAIR hyperintensity in the dentate nuclei bilaterally. Soon after the discontinuation of metronidazole, dysarthria and dysmetria resolved. Metronidazole-induced encephalopathy should be considered in patients presenting with new neurologic symptoms after the initiation of metronidazole.
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spelling pubmed-68049362019-11-05 Metronidazole-induced Encephalopathy Phyu, Htay Edmond, Michael B. Kobayashi, Takaaki IDCases Article Metronidazole is commonly used in the treatment of anaerobic infections. While neuropathy is known to be associated with metronidazole, encephalopathy has been rarely reported. We herein present a case of metronidazole-induced encephalopathy presenting as frequent falls and slurred speech. Magnetic resonance imaging of the brain demonstrated T2/FLAIR hyperintensity in the dentate nuclei bilaterally. Soon after the discontinuation of metronidazole, dysarthria and dysmetria resolved. Metronidazole-induced encephalopathy should be considered in patients presenting with new neurologic symptoms after the initiation of metronidazole. Elsevier 2019-09-07 /pmc/articles/PMC6804936/ /pubmed/31692663 http://dx.doi.org/10.1016/j.idcr.2019.e00639 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Phyu, Htay
Edmond, Michael B.
Kobayashi, Takaaki
Metronidazole-induced Encephalopathy
title Metronidazole-induced Encephalopathy
title_full Metronidazole-induced Encephalopathy
title_fullStr Metronidazole-induced Encephalopathy
title_full_unstemmed Metronidazole-induced Encephalopathy
title_short Metronidazole-induced Encephalopathy
title_sort metronidazole-induced encephalopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804936/
https://www.ncbi.nlm.nih.gov/pubmed/31692663
http://dx.doi.org/10.1016/j.idcr.2019.e00639
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AT kobayashitakaaki metronidazoleinducedencephalopathy

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