Cargando…
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
BACKGROUND: b-AP15/VLX1570 are small molecule inhibitors of the ubiquitin specific peptidase 14 (USP14) and ubiquitin carboxyl-terminal hydrolase 5 (UCHL5) deubiquitinases (DUBs) of the 19S proteasome. b-AP15/VLX1570 have been shown to be cytotoxic to cells resistant to bortezomib, raising the possi...
Autores principales: | Mofers, Arjan, Perego, Paola, Selvaraju, Karthik, Gatti, Laura, Gullbo, Joachim, Linder, Stig, D'Arcy, Padraig |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804958/ https://www.ncbi.nlm.nih.gov/pubmed/31639138 http://dx.doi.org/10.1371/journal.pone.0223807 |
Ejemplares similares
-
Proteasome-associated deubiquitinases and cancer
por: Mofers, Arjan, et al.
Publicado: (2017) -
Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
por: Pellegrini, Paola, et al.
Publicado: (2020) -
Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment
por: Zhang, Xiaonan, et al.
Publicado: (2019) -
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
por: Mazurkiewicz, Magdalena, et al.
Publicado: (2017) -
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
por: Wang, Xin, et al.
Publicado: (2016)