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Liver transplantation in patients with a history of migration—A German single center comparative analysis

Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analy...

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Autores principales: Bucher, Julian Nikolaus, Koenig, Maximilian, Schoenberg, Markus Bo, Crispin, Alexander, Thomas, Michael, Angele, Martin Kurt, Eser-Valeri, Daniela, Gerbes, Alexander Lutz, Werner, Jens, Guba, Markus Otto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804963/
https://www.ncbi.nlm.nih.gov/pubmed/31639158
http://dx.doi.org/10.1371/journal.pone.0224116
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author Bucher, Julian Nikolaus
Koenig, Maximilian
Schoenberg, Markus Bo
Crispin, Alexander
Thomas, Michael
Angele, Martin Kurt
Eser-Valeri, Daniela
Gerbes, Alexander Lutz
Werner, Jens
Guba, Markus Otto
author_facet Bucher, Julian Nikolaus
Koenig, Maximilian
Schoenberg, Markus Bo
Crispin, Alexander
Thomas, Michael
Angele, Martin Kurt
Eser-Valeri, Daniela
Gerbes, Alexander Lutz
Werner, Jens
Guba, Markus Otto
author_sort Bucher, Julian Nikolaus
collection PubMed
description Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analysis of all primary LT between April 2007 and December 2015, stratified for the history of migration to investigate differences in the outcome. We found transplant rates resembling the proportion of persons with a history of migration in the general public in the region of our center. Differences were found concerning age at LT and prevalence of underlying diseases. Re-Transplant rates, Kaplan-Meier Estimates for overall survival, also after stratification for viral hepatitis, sex, ethnicity or presence of a language-barrier showed no statistical differences. The multivariate analysis showed no migration-related covariate associated with a negative outcome. These results stand in contrast to most of the previous evidence from North America and the UK and need to be taken into consideration during the wait-listing process of patients with a history of migration in need of a LT in centers in the Eurotransplant region.
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spelling pubmed-68049632019-11-02 Liver transplantation in patients with a history of migration—A German single center comparative analysis Bucher, Julian Nikolaus Koenig, Maximilian Schoenberg, Markus Bo Crispin, Alexander Thomas, Michael Angele, Martin Kurt Eser-Valeri, Daniela Gerbes, Alexander Lutz Werner, Jens Guba, Markus Otto PLoS One Research Article Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analysis of all primary LT between April 2007 and December 2015, stratified for the history of migration to investigate differences in the outcome. We found transplant rates resembling the proportion of persons with a history of migration in the general public in the region of our center. Differences were found concerning age at LT and prevalence of underlying diseases. Re-Transplant rates, Kaplan-Meier Estimates for overall survival, also after stratification for viral hepatitis, sex, ethnicity or presence of a language-barrier showed no statistical differences. The multivariate analysis showed no migration-related covariate associated with a negative outcome. These results stand in contrast to most of the previous evidence from North America and the UK and need to be taken into consideration during the wait-listing process of patients with a history of migration in need of a LT in centers in the Eurotransplant region. Public Library of Science 2019-10-22 /pmc/articles/PMC6804963/ /pubmed/31639158 http://dx.doi.org/10.1371/journal.pone.0224116 Text en © 2019 Bucher et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bucher, Julian Nikolaus
Koenig, Maximilian
Schoenberg, Markus Bo
Crispin, Alexander
Thomas, Michael
Angele, Martin Kurt
Eser-Valeri, Daniela
Gerbes, Alexander Lutz
Werner, Jens
Guba, Markus Otto
Liver transplantation in patients with a history of migration—A German single center comparative analysis
title Liver transplantation in patients with a history of migration—A German single center comparative analysis
title_full Liver transplantation in patients with a history of migration—A German single center comparative analysis
title_fullStr Liver transplantation in patients with a history of migration—A German single center comparative analysis
title_full_unstemmed Liver transplantation in patients with a history of migration—A German single center comparative analysis
title_short Liver transplantation in patients with a history of migration—A German single center comparative analysis
title_sort liver transplantation in patients with a history of migration—a german single center comparative analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804963/
https://www.ncbi.nlm.nih.gov/pubmed/31639158
http://dx.doi.org/10.1371/journal.pone.0224116
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