Cargando…
Liver transplantation in patients with a history of migration—A German single center comparative analysis
Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analy...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804963/ https://www.ncbi.nlm.nih.gov/pubmed/31639158 http://dx.doi.org/10.1371/journal.pone.0224116 |
_version_ | 1783461295235792896 |
---|---|
author | Bucher, Julian Nikolaus Koenig, Maximilian Schoenberg, Markus Bo Crispin, Alexander Thomas, Michael Angele, Martin Kurt Eser-Valeri, Daniela Gerbes, Alexander Lutz Werner, Jens Guba, Markus Otto |
author_facet | Bucher, Julian Nikolaus Koenig, Maximilian Schoenberg, Markus Bo Crispin, Alexander Thomas, Michael Angele, Martin Kurt Eser-Valeri, Daniela Gerbes, Alexander Lutz Werner, Jens Guba, Markus Otto |
author_sort | Bucher, Julian Nikolaus |
collection | PubMed |
description | Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analysis of all primary LT between April 2007 and December 2015, stratified for the history of migration to investigate differences in the outcome. We found transplant rates resembling the proportion of persons with a history of migration in the general public in the region of our center. Differences were found concerning age at LT and prevalence of underlying diseases. Re-Transplant rates, Kaplan-Meier Estimates for overall survival, also after stratification for viral hepatitis, sex, ethnicity or presence of a language-barrier showed no statistical differences. The multivariate analysis showed no migration-related covariate associated with a negative outcome. These results stand in contrast to most of the previous evidence from North America and the UK and need to be taken into consideration during the wait-listing process of patients with a history of migration in need of a LT in centers in the Eurotransplant region. |
format | Online Article Text |
id | pubmed-6804963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-68049632019-11-02 Liver transplantation in patients with a history of migration—A German single center comparative analysis Bucher, Julian Nikolaus Koenig, Maximilian Schoenberg, Markus Bo Crispin, Alexander Thomas, Michael Angele, Martin Kurt Eser-Valeri, Daniela Gerbes, Alexander Lutz Werner, Jens Guba, Markus Otto PLoS One Research Article Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analysis of all primary LT between April 2007 and December 2015, stratified for the history of migration to investigate differences in the outcome. We found transplant rates resembling the proportion of persons with a history of migration in the general public in the region of our center. Differences were found concerning age at LT and prevalence of underlying diseases. Re-Transplant rates, Kaplan-Meier Estimates for overall survival, also after stratification for viral hepatitis, sex, ethnicity or presence of a language-barrier showed no statistical differences. The multivariate analysis showed no migration-related covariate associated with a negative outcome. These results stand in contrast to most of the previous evidence from North America and the UK and need to be taken into consideration during the wait-listing process of patients with a history of migration in need of a LT in centers in the Eurotransplant region. Public Library of Science 2019-10-22 /pmc/articles/PMC6804963/ /pubmed/31639158 http://dx.doi.org/10.1371/journal.pone.0224116 Text en © 2019 Bucher et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bucher, Julian Nikolaus Koenig, Maximilian Schoenberg, Markus Bo Crispin, Alexander Thomas, Michael Angele, Martin Kurt Eser-Valeri, Daniela Gerbes, Alexander Lutz Werner, Jens Guba, Markus Otto Liver transplantation in patients with a history of migration—A German single center comparative analysis |
title | Liver transplantation in patients with a history of migration—A German single center comparative analysis |
title_full | Liver transplantation in patients with a history of migration—A German single center comparative analysis |
title_fullStr | Liver transplantation in patients with a history of migration—A German single center comparative analysis |
title_full_unstemmed | Liver transplantation in patients with a history of migration—A German single center comparative analysis |
title_short | Liver transplantation in patients with a history of migration—A German single center comparative analysis |
title_sort | liver transplantation in patients with a history of migration—a german single center comparative analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804963/ https://www.ncbi.nlm.nih.gov/pubmed/31639158 http://dx.doi.org/10.1371/journal.pone.0224116 |
work_keys_str_mv | AT bucherjuliannikolaus livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT koenigmaximilian livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT schoenbergmarkusbo livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT crispinalexander livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT thomasmichael livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT angelemartinkurt livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT eservaleridaniela livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT gerbesalexanderlutz livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT wernerjens livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis AT gubamarkusotto livertransplantationinpatientswithahistoryofmigrationagermansinglecentercomparativeanalysis |