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Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
The effect of statin on hemodialysis patients is controversial. Although previous large-scale studies did not clarify its effect in this population, recent studies suggest that statins could be useful in reducing the risk of cardiovascular events and all-cause mortality in specific groups of patient...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804988/ https://www.ncbi.nlm.nih.gov/pubmed/31639169 http://dx.doi.org/10.1371/journal.pone.0224111 |
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author | Ota, Yuki Kitamura, Mineaki Muta, Kumiko Yamashita, Hiroshi Uramatsu, Tadashi Obata, Yoko Harada, Takashi Funakoshi, Satoshi Mukae, Hiroshi Nishino, Tomoya |
author_facet | Ota, Yuki Kitamura, Mineaki Muta, Kumiko Yamashita, Hiroshi Uramatsu, Tadashi Obata, Yoko Harada, Takashi Funakoshi, Satoshi Mukae, Hiroshi Nishino, Tomoya |
author_sort | Ota, Yuki |
collection | PubMed |
description | The effect of statin on hemodialysis patients is controversial. Although previous large-scale studies did not clarify its effect in this population, recent studies suggest that statins could be useful in reducing the risk of cardiovascular events and all-cause mortality in specific groups of patients undergoing hemodialysis. The aforementioned large-scale studies included a small percentage of Asians, and few studies have investigated the effects of statins in Asians undergoing hemodialysis. Thus, we investigated the benefits of statins in patients undergoing maintenance hemodialysis at a single center in Japan. We obtained demographic, clinical, and hemodialysis data of all patients who underwent maintenance hemodialysis at the Nagasaki Renal Center between July 2011 and June 2012. Patients were followed-up until June 2018. We studied 339 patients, of which 51 (15.0%) were prescribed pitavastatin. The mean observation period was 4.1±2.3 years, 43% were women, and the median hemodialysis vintage at baseline was 4.7 years. During the follow-up, 198 patients (58%) died, of which 22 (43%) were prescribed pitavastatin and 176 (61%) were not prescribed any statins. After propensity score matching based on age, sex, dialysis vintage, dialysis time, diabetes mellitus, ischemic heart disease, dry weight, left ventricular ejection fraction, and serum albumin, an intergroup comparison between those who received statins and those who did not (44 patients in each group) showed significant differences in survival rate based on the log-rank test (P<0.05). Although the causes of death did not differ significantly between groups, deaths due to cardiovascular events, infections, and cancer were fewer in the group prescribed statins. Our results suggest that statins may reduce mortality in Japanese patients undergoing maintenance hemodialysis. Although potential residual confounders exist, statins may have an influence on the reduction in the incidence of cardiovascular events, infections, and cancer. Nevertheless, further studies are required to prove this hypothesis. |
format | Online Article Text |
id | pubmed-6804988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-68049882019-11-02 Effect of statin on life prognosis in Japanese patients undergoing hemodialysis Ota, Yuki Kitamura, Mineaki Muta, Kumiko Yamashita, Hiroshi Uramatsu, Tadashi Obata, Yoko Harada, Takashi Funakoshi, Satoshi Mukae, Hiroshi Nishino, Tomoya PLoS One Research Article The effect of statin on hemodialysis patients is controversial. Although previous large-scale studies did not clarify its effect in this population, recent studies suggest that statins could be useful in reducing the risk of cardiovascular events and all-cause mortality in specific groups of patients undergoing hemodialysis. The aforementioned large-scale studies included a small percentage of Asians, and few studies have investigated the effects of statins in Asians undergoing hemodialysis. Thus, we investigated the benefits of statins in patients undergoing maintenance hemodialysis at a single center in Japan. We obtained demographic, clinical, and hemodialysis data of all patients who underwent maintenance hemodialysis at the Nagasaki Renal Center between July 2011 and June 2012. Patients were followed-up until June 2018. We studied 339 patients, of which 51 (15.0%) were prescribed pitavastatin. The mean observation period was 4.1±2.3 years, 43% were women, and the median hemodialysis vintage at baseline was 4.7 years. During the follow-up, 198 patients (58%) died, of which 22 (43%) were prescribed pitavastatin and 176 (61%) were not prescribed any statins. After propensity score matching based on age, sex, dialysis vintage, dialysis time, diabetes mellitus, ischemic heart disease, dry weight, left ventricular ejection fraction, and serum albumin, an intergroup comparison between those who received statins and those who did not (44 patients in each group) showed significant differences in survival rate based on the log-rank test (P<0.05). Although the causes of death did not differ significantly between groups, deaths due to cardiovascular events, infections, and cancer were fewer in the group prescribed statins. Our results suggest that statins may reduce mortality in Japanese patients undergoing maintenance hemodialysis. Although potential residual confounders exist, statins may have an influence on the reduction in the incidence of cardiovascular events, infections, and cancer. Nevertheless, further studies are required to prove this hypothesis. Public Library of Science 2019-10-22 /pmc/articles/PMC6804988/ /pubmed/31639169 http://dx.doi.org/10.1371/journal.pone.0224111 Text en © 2019 Ota et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ota, Yuki Kitamura, Mineaki Muta, Kumiko Yamashita, Hiroshi Uramatsu, Tadashi Obata, Yoko Harada, Takashi Funakoshi, Satoshi Mukae, Hiroshi Nishino, Tomoya Effect of statin on life prognosis in Japanese patients undergoing hemodialysis |
title | Effect of statin on life prognosis in Japanese patients undergoing hemodialysis |
title_full | Effect of statin on life prognosis in Japanese patients undergoing hemodialysis |
title_fullStr | Effect of statin on life prognosis in Japanese patients undergoing hemodialysis |
title_full_unstemmed | Effect of statin on life prognosis in Japanese patients undergoing hemodialysis |
title_short | Effect of statin on life prognosis in Japanese patients undergoing hemodialysis |
title_sort | effect of statin on life prognosis in japanese patients undergoing hemodialysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804988/ https://www.ncbi.nlm.nih.gov/pubmed/31639169 http://dx.doi.org/10.1371/journal.pone.0224111 |
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