2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury

Histone deacetylases 6 (HDAC6) has been reported to be involved in the pathogenesis of rhabdomyolysis-induced acute kidney injury (AKI). Selective inhibition of HDAC6 activity might be a potential treatment for AKI. In our lab, N-hydroxy-6-(4-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)nicotinamid...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Cui, Xue, Guo, Fan, Li, Xinrui, Li, Lingzhi, Pan, Jing, Tao, Sibei, Huang, Rongshuang, Feng, Yanhuan, Ma, Liang, Fu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804997/
https://www.ncbi.nlm.nih.gov/pubmed/31639165
http://dx.doi.org/10.1371/journal.pone.0224158

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