HMNPPID—human malignant neoplasm protein–protein interaction database

BACKGROUND: Protein–protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes. Especially, the PPIs associated with human malignant neoplasms can unveil the biology behind these neoplasms. However, such PPI database is n...

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Autores principales: Li, Qingqing, Yang, Zhihao, Zhao, Zhehuan, Luo, Ling, Li, Zhiheng, Wang, Lei, Zhang, Yin, Lin, Hongfei, Wang, Jian, Zhang, Yijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805303/
https://www.ncbi.nlm.nih.gov/pubmed/31639057
http://dx.doi.org/10.1186/s40246-019-0223-5
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author Li, Qingqing
Yang, Zhihao
Zhao, Zhehuan
Luo, Ling
Li, Zhiheng
Wang, Lei
Zhang, Yin
Lin, Hongfei
Wang, Jian
Zhang, Yijia
author_facet Li, Qingqing
Yang, Zhihao
Zhao, Zhehuan
Luo, Ling
Li, Zhiheng
Wang, Lei
Zhang, Yin
Lin, Hongfei
Wang, Jian
Zhang, Yijia
author_sort Li, Qingqing
collection PubMed
description BACKGROUND: Protein–protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes. Especially, the PPIs associated with human malignant neoplasms can unveil the biology behind these neoplasms. However, such PPI database is not currently available. RESULTS: In this work, a database of protein–protein interactions associated with 171 kinds of human malignant neoplasms named HMNPPID is constructed. In addition, a visualization program, named VisualPPI, is provided to facilitate the analysis of the PPI network for a specific neoplasm. CONCLUSIONS: HMNPPID can hopefully become an important resource for the research on PPIs of human malignant neoplasms since it provides readily available data for healthcare professionals. Thus, they do not need to dig into a large amount of biomedical literatures any more, which may accelerate the researches on the PPIs of malignant neoplasms.
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spelling pubmed-68053032019-10-24 HMNPPID—human malignant neoplasm protein–protein interaction database Li, Qingqing Yang, Zhihao Zhao, Zhehuan Luo, Ling Li, Zhiheng Wang, Lei Zhang, Yin Lin, Hongfei Wang, Jian Zhang, Yijia Hum Genomics Research BACKGROUND: Protein–protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes. Especially, the PPIs associated with human malignant neoplasms can unveil the biology behind these neoplasms. However, such PPI database is not currently available. RESULTS: In this work, a database of protein–protein interactions associated with 171 kinds of human malignant neoplasms named HMNPPID is constructed. In addition, a visualization program, named VisualPPI, is provided to facilitate the analysis of the PPI network for a specific neoplasm. CONCLUSIONS: HMNPPID can hopefully become an important resource for the research on PPIs of human malignant neoplasms since it provides readily available data for healthcare professionals. Thus, they do not need to dig into a large amount of biomedical literatures any more, which may accelerate the researches on the PPIs of malignant neoplasms. BioMed Central 2019-10-22 /pmc/articles/PMC6805303/ /pubmed/31639057 http://dx.doi.org/10.1186/s40246-019-0223-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Li, Qingqing
Yang, Zhihao
Zhao, Zhehuan
Luo, Ling
Li, Zhiheng
Wang, Lei
Zhang, Yin
Lin, Hongfei
Wang, Jian
Zhang, Yijia
HMNPPID—human malignant neoplasm protein–protein interaction database
title HMNPPID—human malignant neoplasm protein–protein interaction database
title_full HMNPPID—human malignant neoplasm protein–protein interaction database
title_fullStr HMNPPID—human malignant neoplasm protein–protein interaction database
title_full_unstemmed HMNPPID—human malignant neoplasm protein–protein interaction database
title_short HMNPPID—human malignant neoplasm protein–protein interaction database
title_sort hmnppid—human malignant neoplasm protein–protein interaction database
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805303/
https://www.ncbi.nlm.nih.gov/pubmed/31639057
http://dx.doi.org/10.1186/s40246-019-0223-5
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