Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice

BACKGROUND: Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and temporal lobes, altered synaptic connectivity, and behavioral alterations. MET...

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Detalles Bibliográficos
Autores principales: Nagy, Dávid, Martens, Lauren Herl, Leventhal, Liza, Chen, Angela, Kelley, Craig, Stoiljkovic, Milan, Hajós, Mihály
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805349/
https://www.ncbi.nlm.nih.gov/pubmed/31639062
http://dx.doi.org/10.1186/s13195-019-0540-x

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