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Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease

BACKGROUND: Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptoms burden was associated with cortical thickness and subcortical nuclei volume i...

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Autores principales: Niccolini, Flavia, Wilson, Heather, Giordano, Beniamino, Diamantopoulos, Konstantinos, Pagano, Gennaro, Chaudhuri, Kallol Ray, Politis, Marios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805461/
https://www.ncbi.nlm.nih.gov/pubmed/31640554
http://dx.doi.org/10.1186/s12868-019-0537-1
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author Niccolini, Flavia
Wilson, Heather
Giordano, Beniamino
Diamantopoulos, Konstantinos
Pagano, Gennaro
Chaudhuri, Kallol Ray
Politis, Marios
author_facet Niccolini, Flavia
Wilson, Heather
Giordano, Beniamino
Diamantopoulos, Konstantinos
Pagano, Gennaro
Chaudhuri, Kallol Ray
Politis, Marios
author_sort Niccolini, Flavia
collection PubMed
description BACKGROUND: Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptoms burden was associated with cortical thickness and subcortical nuclei volume in PD patients. METHODS: We studied 41 non-demented PD patients. Non-motor symptoms burden was assessed using the Non-Motor Symptoms Scale grading (NMSS). Cortical thickness and subcortical nuclei volume analyses were carried out using Free-Surfer. PD patients were divided into two groups according to the NMSS grading: mild to moderate (NMSS: 0–40) and severe (NMSS: ≥ 41) non-motor symptoms. RESULTS: Thalamic atrophy was associated with higher NMSQ and NMSS total scores. The non-motor symptoms that drove this correlation were sleep/fatigue and gastrointestinal tract dysfunction. We also found that PD patients with severe non-motor symptoms had significant thalamic atrophy compared to the group with mild to moderate non-motor symptoms. CONCLUSIONS: Our findings show that greater non-motor symptom burden is associated with thalamic atrophy in PD. Thalamus plays an important role in processing sensory information including visceral afferent from the gastrointestinal tract and in regulating states of sleep and wakefulness.
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spelling pubmed-68054612019-10-24 Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease Niccolini, Flavia Wilson, Heather Giordano, Beniamino Diamantopoulos, Konstantinos Pagano, Gennaro Chaudhuri, Kallol Ray Politis, Marios BMC Neurosci Research Article BACKGROUND: Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptoms burden was associated with cortical thickness and subcortical nuclei volume in PD patients. METHODS: We studied 41 non-demented PD patients. Non-motor symptoms burden was assessed using the Non-Motor Symptoms Scale grading (NMSS). Cortical thickness and subcortical nuclei volume analyses were carried out using Free-Surfer. PD patients were divided into two groups according to the NMSS grading: mild to moderate (NMSS: 0–40) and severe (NMSS: ≥ 41) non-motor symptoms. RESULTS: Thalamic atrophy was associated with higher NMSQ and NMSS total scores. The non-motor symptoms that drove this correlation were sleep/fatigue and gastrointestinal tract dysfunction. We also found that PD patients with severe non-motor symptoms had significant thalamic atrophy compared to the group with mild to moderate non-motor symptoms. CONCLUSIONS: Our findings show that greater non-motor symptom burden is associated with thalamic atrophy in PD. Thalamus plays an important role in processing sensory information including visceral afferent from the gastrointestinal tract and in regulating states of sleep and wakefulness. BioMed Central 2019-10-22 /pmc/articles/PMC6805461/ /pubmed/31640554 http://dx.doi.org/10.1186/s12868-019-0537-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Niccolini, Flavia
Wilson, Heather
Giordano, Beniamino
Diamantopoulos, Konstantinos
Pagano, Gennaro
Chaudhuri, Kallol Ray
Politis, Marios
Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
title Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
title_full Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
title_fullStr Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
title_full_unstemmed Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
title_short Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
title_sort sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805461/
https://www.ncbi.nlm.nih.gov/pubmed/31640554
http://dx.doi.org/10.1186/s12868-019-0537-1
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