The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation

BACKGROUND: Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein products. Translating ribosomes that encounter po...

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Detalles Bibliográficos
Autores principales: Hildebrandt, Andrea, Brüggemann, Mirko, Rücklé, Cornelia, Boerner, Susan, Heidelberger, Jan B., Busch, Anke, Hänel, Heike, Voigt, Andrea, Möckel, Martin M., Ebersberger, Stefanie, Scholz, Anica, Dold, Annabelle, Schmid, Tobias, Ebersberger, Ingo, Roignant, Jean-Yves, Zarnack, Kathi, König, Julian, Beli, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805484/
https://www.ncbi.nlm.nih.gov/pubmed/31640799
http://dx.doi.org/10.1186/s13059-019-1814-0

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