A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT

Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript descri...

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Detalles Bibliográficos
Autores principales: Kohlert, Scott, McLean, Laurie, Scarvelis, Dimitrios, Thompson, Calvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805523/
https://www.ncbi.nlm.nih.gov/pubmed/31640785
http://dx.doi.org/10.1186/s40463-019-0369-0
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author Kohlert, Scott
McLean, Laurie
Scarvelis, Dimitrios
Thompson, Calvin
author_facet Kohlert, Scott
McLean, Laurie
Scarvelis, Dimitrios
Thompson, Calvin
author_sort Kohlert, Scott
collection PubMed
description Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication.
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spelling pubmed-68055232019-10-24 A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT Kohlert, Scott McLean, Laurie Scarvelis, Dimitrios Thompson, Calvin J Otolaryngol Head Neck Surg Case Report Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication. BioMed Central 2019-10-22 /pmc/articles/PMC6805523/ /pubmed/31640785 http://dx.doi.org/10.1186/s40463-019-0369-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kohlert, Scott
McLean, Laurie
Scarvelis, Dimitrios
Thompson, Calvin
A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
title A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
title_full A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
title_fullStr A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
title_full_unstemmed A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
title_short A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
title_sort case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including hbot
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805523/
https://www.ncbi.nlm.nih.gov/pubmed/31640785
http://dx.doi.org/10.1186/s40463-019-0369-0
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