Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation

Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed t...

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Autores principales: Tornese, Gianluca, Pricci, Flavia, Pellegrin, Maria Chiara, Villa, Marika, Rotondi, Daniela, Agazio, Elvira, Barbi, Egidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805524/
https://www.ncbi.nlm.nih.gov/pubmed/31639023
http://dx.doi.org/10.1186/s13052-019-0715-x
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author Tornese, Gianluca
Pricci, Flavia
Pellegrin, Maria Chiara
Villa, Marika
Rotondi, Daniela
Agazio, Elvira
Barbi, Egidio
author_facet Tornese, Gianluca
Pricci, Flavia
Pellegrin, Maria Chiara
Villa, Marika
Rotondi, Daniela
Agazio, Elvira
Barbi, Egidio
author_sort Tornese, Gianluca
collection PubMed
description Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed that the number of children treated with SGA indication is still small (prevalence 0.37/100,000) and these children are significantly less reported than those treated for growth hormone deficiency (GHD), although GHD prevalence is 1:4000–1:10,000. This means that many short children born SGA are still not properly identified, and therefore not treated with rhGH, or misdiagnosed as GHD. This article provides some practical tools for the identification of children eligible for rhGH treatment.
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spelling pubmed-68055242019-10-24 Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation Tornese, Gianluca Pricci, Flavia Pellegrin, Maria Chiara Villa, Marika Rotondi, Daniela Agazio, Elvira Barbi, Egidio Ital J Pediatr Commentary Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed that the number of children treated with SGA indication is still small (prevalence 0.37/100,000) and these children are significantly less reported than those treated for growth hormone deficiency (GHD), although GHD prevalence is 1:4000–1:10,000. This means that many short children born SGA are still not properly identified, and therefore not treated with rhGH, or misdiagnosed as GHD. This article provides some practical tools for the identification of children eligible for rhGH treatment. BioMed Central 2019-10-21 /pmc/articles/PMC6805524/ /pubmed/31639023 http://dx.doi.org/10.1186/s13052-019-0715-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Tornese, Gianluca
Pricci, Flavia
Pellegrin, Maria Chiara
Villa, Marika
Rotondi, Daniela
Agazio, Elvira
Barbi, Egidio
Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
title Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
title_full Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
title_fullStr Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
title_full_unstemmed Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
title_short Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
title_sort practical tools to identify short children born small-for-gestational-age eligible for rhgh treatment according to italian regulation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805524/
https://www.ncbi.nlm.nih.gov/pubmed/31639023
http://dx.doi.org/10.1186/s13052-019-0715-x
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