Cargando…

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

BACKGROUND: Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell population, is resonsible for driving the tumor maintenance and metastasis, and is a source of chemotherapy and radiation-therapy resistance within tumors. Targeting CICs self-renewal has been proposed as a therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jinhua, Xing, Yajing, Wang, Yingying, He, Yundong, Wang, Liting, Peng, Shihong, Yang, Lianfang, Xie, Jiuqing, Li, Xiaotao, Qiu, Wenwei, Yi, Zhengfang, Liu, Mingyao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805542/ https://www.ncbi.nlm.nih.gov/pubmed/31640758 http://dx.doi.org/10.1186/s13046-019-1392-8

Ejemplares similares

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer
por: Hu, Meichun, et al.
Publicado: (2015)

Pancreatitis Incidence in the Exenatide BID, Exenatide QW, and Exenatide QW Suspension Development Programs: Pooled Analysis of 35 Clinical Trials
por: Vetter, Marion L., et al.
Publicado: (2019)

Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
por: He, Yundong, et al.
Publicado: (2016)

Ailanthone: a new potential drug for castration-resistant prostate cancer
por: Peng, Shihong, et al.
Publicado: (2017)

Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer
por: Chen, Huiqing, et al.
Publicado: (2019)

Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122
por: Cong, Xiaonan, et al.
Publicado: (2021)

Technical specification for ultrahigh vacuum chambers for the antiproton accumulator wide quadrupoles (QW)
Publicado: (1979)

High potential application in bioremediation of selenate by Proteus hauseri strain QW4
por: Khalilian, Mohaddeseh, et al.
Publicado: (2015)

Barrier thickness dependence of Mg(x)Zn(1−x)O/ZnO quantum well (QW) on the performance of a p-NiO/QW/n-ZnO photodiode
por: Hwang, Jun Dar, et al.
Publicado: (2019)

First Complete Genome Sequence of a Genogroup II Genotype 18 Porcine Norovirus, Strain QW125
por: Oka, Tomoichiro, et al.
Publicado: (2013)

A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis viaFAK pathway
por: Dai, Fujun, et al.
Publicado: (2015)

Photoluminescence and Band Alignment of Strained GaAsSb/GaAs QW Structures Grown by MBE on GaAs
por: Sadofyev, Yuri G., et al.
Publicado: (2010)

Optimizing Levilactobacillus brevis NPS-QW 145 Fermentation for Gamma-Aminobutyric Acid (GABA) Production in Soybean Sprout Yogurt-like Product
por: Zhang, Yue, et al.
Publicado: (2023)

Improving the internal quantum efficiency of QD/QW hybrid structures by increasing the GaN barrier thickness
por: Jia, Zhigang, et al.
Publicado: (2020)

Effect of exenatide QW or placebo, both added to titrated insulin glargine, in uncontrolled type 2 diabetes: The DURATION‐7 randomized study
por: Guja, Cristian, et al.
Publicado: (2018)

The Cost-effectiveness of Dulaglutide 1.5mg versus Exenatide QW for the Treatment of Patients with Type 2 Diabetes Mellitus in France
por: Basson, Mickael, et al.
Publicado: (2017)

Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway
por: Li, Chenghai, et al.
Publicado: (2010)

PubAngioGen: a database and knowledge for angiogenesis and related diseases
por: Li, Peng, et al.
Publicado: (2014)

An indirect comparison of HbA(1c) treatment effect with albiglutide and exenatide 2.0 mg QW using the Bucher method
por: Martin, Alan A, et al.
Publicado: (2016)

Stimulated Emission up to 2.75 µm from HgCdTe/CdHgTe QW Structure at Room Temperature
por: Utochkin, Vladimir V., et al.
Publicado: (2022)

Search for massive resonances decaying into WW, WZ, ZZ, qW, and qZ with dijet final states at $\sqrt{s} =$ 13 TeV
por: Sirunyan, Albert M, et al.
Publicado: (2017)

Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
por: Chen, Huang, et al.
Publicado: (2021)

Specification technique pour les chambres a vide des aimants quadripoles larges (QW) de l'anneau accumulateur d'antiprotons
Publicado: (1979)

Dairy Streptococcus thermophilus improves cell viability of Lactobacillus brevis NPS-QW-145 and its γ-aminobutyric acid biosynthesis ability in milk
por: Wu, Qinglong, et al.
Publicado: (2015)

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
por: Lin, Qingxiang, et al.
Publicado: (2020)

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
por: Lu, Weiqiang, et al.
Publicado: (2020)

Search for massive resonances decaying into WW, WZ, ZZ, qW and qZ in the dijet final state at $\sqrt{s} = 13~\mathrm{TeV}$
por: CMS Collaboration
Publicado: (2017)

Gender Differences in the Effects of BMI on School Bullying and Victimization in China: Comparing Normal Weight, Underweight and Overweight Secondary School Students
por: Xie, Yang, et al.
Publicado: (2022)

A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression
por: He, Yuan, et al.
Publicado: (2021)

The prognostic impact of BMI on colorectal cancer is stratified by tumor location
por: Zhang, Zixi, et al.
Publicado: (2022)

BMI and the risk of colorectal adenoma in African Americans
por: Ashktorab, Hassan, et al.
Publicado: (2014)

Associations between 24-h movement behaviours and BMI in Chinese primary- and middle- school students
por: Chen, Huan, et al.
Publicado: (2023)

Whole-Genome Analysis of Escherichia Phage vB_EcoM-S1P5QW, Isolated from Manures Collected from Cattle Farms in Maine
por: Quintela, Irwin A., et al.
Publicado: (2022)

Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer
por: Su, Ning, et al.
Publicado: (2012)

The Beijing Electron-positron Collider and its Second Phase Construction
por: Wang, Jiuqing
Publicado: (2004)

Search for qW/qZ/WW/WZ/ZZ-Resonances in the W/Z-tagged Dijet Mass Spectrum from 7 TeV pp Collisions at CMS
por: CMS Collaboration
Publicado: (2012)

Search for massive resonances decaying into WW, WZ, ZZ, qW and qZ in the dijet final state at $\sqrt{s} = 13~\mathrm{TeV}$ using 2016 data
por: CMS Collaboration
Publicado: (2016)

Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study
por: Yuan, Chun, et al.
Publicado: (2016)

Correction: Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer
por: Su, Ning, et al.
Publicado: (2012)

Body mass index (BMI) trajectories and risk of colorectal cancer in the PLCO cohort
por: Zheng, Rui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c3uq126gdsovo5p1i44itm6jpo