Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression

BACKGROUND: Osteoarthritis (OA) is one of the most prevalent joint disease, and there are still no effective therapeutic agents or clinical methods for the cure of this disease to date. The degradation of cartilage extracellular matrix (ECM) is a major cause of OA. METHOD: IL-1β was used to induce c...

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Detalles Bibliográficos
Autores principales: Duan, Biao, Liu, Yan, Hu, He, Shi, Fu-Guo, Liu, Ya-Long, Xue, Hao, Yun, Xin-Yu, Yan, Ming-Yu, Han, Xi-Rui, Chen, An-Fu, Wang, Yong, Li, Zhe-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805603/
https://www.ncbi.nlm.nih.gov/pubmed/31640732
http://dx.doi.org/10.1186/s12964-019-0443-2

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