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Perspective on Pulsed Electric Field Treatment in the Bio-based Industry

The bio-based industry is urged to find solutions to meet the demands of a growing world population. In this context, increased resource efficiency is a major goal. Pulsed electric field (PEF) processing is a promising technological solution. Conventional PEF and the emerging area of nanosecond PEF...

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Detalles Bibliográficos
Autores principales: Buchmann, Leandro, Mathys, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805697/
https://www.ncbi.nlm.nih.gov/pubmed/31681745
http://dx.doi.org/10.3389/fbioe.2019.00265
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author Buchmann, Leandro
Mathys, Alexander
author_facet Buchmann, Leandro
Mathys, Alexander
author_sort Buchmann, Leandro
collection PubMed
description The bio-based industry is urged to find solutions to meet the demands of a growing world population. In this context, increased resource efficiency is a major goal. Pulsed electric field (PEF) processing is a promising technological solution. Conventional PEF and the emerging area of nanosecond PEF (nsPEF) have been shown to induce various biological effects, with nsPEF inducing pronounced intracellular effects, which could provide solutions for currently faced challenges. Based on the flexibility and continuous operation of PEF and nsPEF processing, the technology can be integrated into many existing cultivation systems; its modularity provides an approach for inducing specific effects. Depending on the treatment conditions, selective inactivation, continuous extraction without impeding cell viability, as well as the stimulation of cell growth and/or cellular compound stimulation are potential applications in the bio-based industry. However, continuous treatment currently involves heterogeneous energy inputs. Increasing the homogeneity of PEF and nsPEF processing by considering the flow and electric field heterogeneity may allow for more targeted effects on biological cells, further increasing the potential of the technology for bio-based applications. We provide an overview of existing and potential applications of PEF and nsPEF and suggest that theoretical and practical analyses of flow and electric field heterogeneity may provide a basis for obtaining more targeted effects on biological cells and for further increasing the bio-based applications of the technology, which thereby could become a key technology for circular economy approaches in the future.
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spelling pubmed-68056972019-11-01 Perspective on Pulsed Electric Field Treatment in the Bio-based Industry Buchmann, Leandro Mathys, Alexander Front Bioeng Biotechnol Bioengineering and Biotechnology The bio-based industry is urged to find solutions to meet the demands of a growing world population. In this context, increased resource efficiency is a major goal. Pulsed electric field (PEF) processing is a promising technological solution. Conventional PEF and the emerging area of nanosecond PEF (nsPEF) have been shown to induce various biological effects, with nsPEF inducing pronounced intracellular effects, which could provide solutions for currently faced challenges. Based on the flexibility and continuous operation of PEF and nsPEF processing, the technology can be integrated into many existing cultivation systems; its modularity provides an approach for inducing specific effects. Depending on the treatment conditions, selective inactivation, continuous extraction without impeding cell viability, as well as the stimulation of cell growth and/or cellular compound stimulation are potential applications in the bio-based industry. However, continuous treatment currently involves heterogeneous energy inputs. Increasing the homogeneity of PEF and nsPEF processing by considering the flow and electric field heterogeneity may allow for more targeted effects on biological cells, further increasing the potential of the technology for bio-based applications. We provide an overview of existing and potential applications of PEF and nsPEF and suggest that theoretical and practical analyses of flow and electric field heterogeneity may provide a basis for obtaining more targeted effects on biological cells and for further increasing the bio-based applications of the technology, which thereby could become a key technology for circular economy approaches in the future. Frontiers Media S.A. 2019-10-16 /pmc/articles/PMC6805697/ /pubmed/31681745 http://dx.doi.org/10.3389/fbioe.2019.00265 Text en Copyright © 2019 Buchmann and Mathys. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Buchmann, Leandro
Mathys, Alexander
Perspective on Pulsed Electric Field Treatment in the Bio-based Industry
title Perspective on Pulsed Electric Field Treatment in the Bio-based Industry
title_full Perspective on Pulsed Electric Field Treatment in the Bio-based Industry
title_fullStr Perspective on Pulsed Electric Field Treatment in the Bio-based Industry
title_full_unstemmed Perspective on Pulsed Electric Field Treatment in the Bio-based Industry
title_short Perspective on Pulsed Electric Field Treatment in the Bio-based Industry
title_sort perspective on pulsed electric field treatment in the bio-based industry
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805697/
https://www.ncbi.nlm.nih.gov/pubmed/31681745
http://dx.doi.org/10.3389/fbioe.2019.00265
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