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Respiratory syncytial virus hospitalisations among young children: a data linkage study

We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of lab...

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Autores principales: Prasad, Namrata, Newbern, E. Claire, Trenholme, Adrian A., Wood, Tim, Thompson, Mark G., Aminisani, Nayyereh, Huang, Q. Sue, Grant, Cameron C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805750/
https://www.ncbi.nlm.nih.gov/pubmed/31364578
http://dx.doi.org/10.1017/S0950268819001377
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author Prasad, Namrata
Newbern, E. Claire
Trenholme, Adrian A.
Wood, Tim
Thompson, Mark G.
Aminisani, Nayyereh
Huang, Q. Sue
Grant, Cameron C.
author_facet Prasad, Namrata
Newbern, E. Claire
Trenholme, Adrian A.
Wood, Tim
Thompson, Mark G.
Aminisani, Nayyereh
Huang, Q. Sue
Grant, Cameron C.
author_sort Prasad, Namrata
collection PubMed
description We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of laboratory-confirmed RSV hospitalisations in children aged <5 years in Auckland, New Zealand (NZ). Incidence rates were estimated by fine age group, ethnicity and socio-economic status (SES) strata. Additionally, RSV disease estimates determined through active surveillance were compared to rates estimated from hospital discharge codes. There were 5309 ARI hospitalisations among children during the study period, of which 3923 (73.9%) were tested for RSV and 1597 (40.7%) were RSV-positive. The seasonal incidence of RSV-associated ARI hospitalisations, once corrected for non-testing, was 6.1 (95% confidence intervals 5.8–6.4) per 1000 children <5 years old. The highest incidence was among children aged <3 months. Being of indigenous Māori or Pacific ethnicity or living in a neighbourhood with low SES independently increased the risk of an RSV-associated hospitalisation. RSV hospital discharge codes had a sensitivity of 71% for identifying laboratory-confirmed RSV cases. RSV infection is a leading cause of hospitalisation among children in NZ, with significant disparities by ethnicity and SES. Our findings highlight the need for effective RSV vaccines and therapies.
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spelling pubmed-68057502019-11-01 Respiratory syncytial virus hospitalisations among young children: a data linkage study Prasad, Namrata Newbern, E. Claire Trenholme, Adrian A. Wood, Tim Thompson, Mark G. Aminisani, Nayyereh Huang, Q. Sue Grant, Cameron C. Epidemiol Infect Original Paper We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of laboratory-confirmed RSV hospitalisations in children aged <5 years in Auckland, New Zealand (NZ). Incidence rates were estimated by fine age group, ethnicity and socio-economic status (SES) strata. Additionally, RSV disease estimates determined through active surveillance were compared to rates estimated from hospital discharge codes. There were 5309 ARI hospitalisations among children during the study period, of which 3923 (73.9%) were tested for RSV and 1597 (40.7%) were RSV-positive. The seasonal incidence of RSV-associated ARI hospitalisations, once corrected for non-testing, was 6.1 (95% confidence intervals 5.8–6.4) per 1000 children <5 years old. The highest incidence was among children aged <3 months. Being of indigenous Māori or Pacific ethnicity or living in a neighbourhood with low SES independently increased the risk of an RSV-associated hospitalisation. RSV hospital discharge codes had a sensitivity of 71% for identifying laboratory-confirmed RSV cases. RSV infection is a leading cause of hospitalisation among children in NZ, with significant disparities by ethnicity and SES. Our findings highlight the need for effective RSV vaccines and therapies. Cambridge University Press 2019-07-29 /pmc/articles/PMC6805750/ /pubmed/31364578 http://dx.doi.org/10.1017/S0950268819001377 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Prasad, Namrata
Newbern, E. Claire
Trenholme, Adrian A.
Wood, Tim
Thompson, Mark G.
Aminisani, Nayyereh
Huang, Q. Sue
Grant, Cameron C.
Respiratory syncytial virus hospitalisations among young children: a data linkage study
title Respiratory syncytial virus hospitalisations among young children: a data linkage study
title_full Respiratory syncytial virus hospitalisations among young children: a data linkage study
title_fullStr Respiratory syncytial virus hospitalisations among young children: a data linkage study
title_full_unstemmed Respiratory syncytial virus hospitalisations among young children: a data linkage study
title_short Respiratory syncytial virus hospitalisations among young children: a data linkage study
title_sort respiratory syncytial virus hospitalisations among young children: a data linkage study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805750/
https://www.ncbi.nlm.nih.gov/pubmed/31364578
http://dx.doi.org/10.1017/S0950268819001377
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