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Respiratory syncytial virus hospitalisations among young children: a data linkage study
We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of lab...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805750/ https://www.ncbi.nlm.nih.gov/pubmed/31364578 http://dx.doi.org/10.1017/S0950268819001377 |
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author | Prasad, Namrata Newbern, E. Claire Trenholme, Adrian A. Wood, Tim Thompson, Mark G. Aminisani, Nayyereh Huang, Q. Sue Grant, Cameron C. |
author_facet | Prasad, Namrata Newbern, E. Claire Trenholme, Adrian A. Wood, Tim Thompson, Mark G. Aminisani, Nayyereh Huang, Q. Sue Grant, Cameron C. |
author_sort | Prasad, Namrata |
collection | PubMed |
description | We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of laboratory-confirmed RSV hospitalisations in children aged <5 years in Auckland, New Zealand (NZ). Incidence rates were estimated by fine age group, ethnicity and socio-economic status (SES) strata. Additionally, RSV disease estimates determined through active surveillance were compared to rates estimated from hospital discharge codes. There were 5309 ARI hospitalisations among children during the study period, of which 3923 (73.9%) were tested for RSV and 1597 (40.7%) were RSV-positive. The seasonal incidence of RSV-associated ARI hospitalisations, once corrected for non-testing, was 6.1 (95% confidence intervals 5.8–6.4) per 1000 children <5 years old. The highest incidence was among children aged <3 months. Being of indigenous Māori or Pacific ethnicity or living in a neighbourhood with low SES independently increased the risk of an RSV-associated hospitalisation. RSV hospital discharge codes had a sensitivity of 71% for identifying laboratory-confirmed RSV cases. RSV infection is a leading cause of hospitalisation among children in NZ, with significant disparities by ethnicity and SES. Our findings highlight the need for effective RSV vaccines and therapies. |
format | Online Article Text |
id | pubmed-6805750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68057502019-11-01 Respiratory syncytial virus hospitalisations among young children: a data linkage study Prasad, Namrata Newbern, E. Claire Trenholme, Adrian A. Wood, Tim Thompson, Mark G. Aminisani, Nayyereh Huang, Q. Sue Grant, Cameron C. Epidemiol Infect Original Paper We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of laboratory-confirmed RSV hospitalisations in children aged <5 years in Auckland, New Zealand (NZ). Incidence rates were estimated by fine age group, ethnicity and socio-economic status (SES) strata. Additionally, RSV disease estimates determined through active surveillance were compared to rates estimated from hospital discharge codes. There were 5309 ARI hospitalisations among children during the study period, of which 3923 (73.9%) were tested for RSV and 1597 (40.7%) were RSV-positive. The seasonal incidence of RSV-associated ARI hospitalisations, once corrected for non-testing, was 6.1 (95% confidence intervals 5.8–6.4) per 1000 children <5 years old. The highest incidence was among children aged <3 months. Being of indigenous Māori or Pacific ethnicity or living in a neighbourhood with low SES independently increased the risk of an RSV-associated hospitalisation. RSV hospital discharge codes had a sensitivity of 71% for identifying laboratory-confirmed RSV cases. RSV infection is a leading cause of hospitalisation among children in NZ, with significant disparities by ethnicity and SES. Our findings highlight the need for effective RSV vaccines and therapies. Cambridge University Press 2019-07-29 /pmc/articles/PMC6805750/ /pubmed/31364578 http://dx.doi.org/10.1017/S0950268819001377 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Prasad, Namrata Newbern, E. Claire Trenholme, Adrian A. Wood, Tim Thompson, Mark G. Aminisani, Nayyereh Huang, Q. Sue Grant, Cameron C. Respiratory syncytial virus hospitalisations among young children: a data linkage study |
title | Respiratory syncytial virus hospitalisations among young children: a data linkage study |
title_full | Respiratory syncytial virus hospitalisations among young children: a data linkage study |
title_fullStr | Respiratory syncytial virus hospitalisations among young children: a data linkage study |
title_full_unstemmed | Respiratory syncytial virus hospitalisations among young children: a data linkage study |
title_short | Respiratory syncytial virus hospitalisations among young children: a data linkage study |
title_sort | respiratory syncytial virus hospitalisations among young children: a data linkage study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805750/ https://www.ncbi.nlm.nih.gov/pubmed/31364578 http://dx.doi.org/10.1017/S0950268819001377 |
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