IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson’s disease

Abnormal aggregation of misfolded pathological proteins in neurons is a prominent feature of neurodegenerative disorders including Parkinson’s disease (PD). Perturbations of proteostasis at the endoplasmic reticulum (ER) triggers ER stress, activating the unfolded protein response (UPR). Chronic ER...

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Detalles Bibliográficos
Autores principales: Yan, Cheng, Liu, Jingqi, Gao, Jiamei, Sun, Ying, Zhang, Lei, Song, Haiyun, Xue, Lei, Zhan, Lixing, Gao, Guanjun, Ke, Zunji, Liu, Yong, Liu, Jingnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805898/
https://www.ncbi.nlm.nih.gov/pubmed/31641108
http://dx.doi.org/10.1038/s41419-019-2039-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805898/
https://www.ncbi.nlm.nih.gov/pubmed/31641108
http://dx.doi.org/10.1038/s41419-019-2039-6

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