DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone

Chronic pediatric inflammatory bowel disease (IBD) leads to lack of bone accrual, bone loss, and increased fractures. Presently there is no cure, and many IBD treatments incur negative side effects. We previously discovered treatment with exogenous irisin resolved inflammatory changes in the colon,...

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Detalles Bibliográficos
Autores principales: Metzger, Corinne E., Narayanan, S. Anand, Elizondo, Jon P., Carter, Anne Michal, Zawieja, David C., Hogan, Harry A., Bloomfield, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805923/
https://www.ncbi.nlm.nih.gov/pubmed/31641205
http://dx.doi.org/10.1038/s41598-019-51550-w

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