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Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images

Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma,...

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Autores principales: Tatewaki, Yasuko, Mutoh, Tatsushi, Omodaka, Kazuko, Thyreau, Benjamin, Matsudaira, Izumi, Furukawa, Hiroaki, Yamada, Keiji, Kunitoki, Keiko, Kawashima, Ryuta, Nakazawa, Toru, Taki, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805949/
https://www.ncbi.nlm.nih.gov/pubmed/31641173
http://dx.doi.org/10.1038/s41598-019-51611-0
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author Tatewaki, Yasuko
Mutoh, Tatsushi
Omodaka, Kazuko
Thyreau, Benjamin
Matsudaira, Izumi
Furukawa, Hiroaki
Yamada, Keiji
Kunitoki, Keiko
Kawashima, Ryuta
Nakazawa, Toru
Taki, Yasuyuki
author_facet Tatewaki, Yasuko
Mutoh, Tatsushi
Omodaka, Kazuko
Thyreau, Benjamin
Matsudaira, Izumi
Furukawa, Hiroaki
Yamada, Keiji
Kunitoki, Keiko
Kawashima, Ryuta
Nakazawa, Toru
Taki, Yasuyuki
author_sort Tatewaki, Yasuko
collection PubMed
description Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma, have not been well described. The aim of this study was to investigate the three-dimensional (3D) topographic features of glaucomatous eyeballs with/without myopia to evaluate the potential of those features for predicting glaucoma. Using a 3.0-tesla MRI, volume-isotropic turbo-spin-echo acquisition T2-weighted images were obtained from 55 patients with glaucoma and 22 controls to delineate the eyeballs. Eyeball volumes, axial lengths and transverse lengths were semi-automatically calculated and compared between four groups: normal, myopia, glaucoma, and glaucoma with myopia. Both glaucoma and myopia increased the eyeball volume compared to the normal eyes. An increased anisotropy ratio (axial/transversus length) was observed in myopic eyes compared to normal, whereas in the glaucomatous eyes, with or without myopia, no increase in anisotropy ratio was observed. Increasing volume of eyes can be caused by myopia and glaucoma. Myopic eyes were ellipsoid in shape, but there was less anisotropy and a near-spherical shape in glaucomatous eyes, even in glaucomatous myopic eyes.
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spelling pubmed-68059492019-10-24 Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images Tatewaki, Yasuko Mutoh, Tatsushi Omodaka, Kazuko Thyreau, Benjamin Matsudaira, Izumi Furukawa, Hiroaki Yamada, Keiji Kunitoki, Keiko Kawashima, Ryuta Nakazawa, Toru Taki, Yasuyuki Sci Rep Article Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma, have not been well described. The aim of this study was to investigate the three-dimensional (3D) topographic features of glaucomatous eyeballs with/without myopia to evaluate the potential of those features for predicting glaucoma. Using a 3.0-tesla MRI, volume-isotropic turbo-spin-echo acquisition T2-weighted images were obtained from 55 patients with glaucoma and 22 controls to delineate the eyeballs. Eyeball volumes, axial lengths and transverse lengths were semi-automatically calculated and compared between four groups: normal, myopia, glaucoma, and glaucoma with myopia. Both glaucoma and myopia increased the eyeball volume compared to the normal eyes. An increased anisotropy ratio (axial/transversus length) was observed in myopic eyes compared to normal, whereas in the glaucomatous eyes, with or without myopia, no increase in anisotropy ratio was observed. Increasing volume of eyes can be caused by myopia and glaucoma. Myopic eyes were ellipsoid in shape, but there was less anisotropy and a near-spherical shape in glaucomatous eyes, even in glaucomatous myopic eyes. Nature Publishing Group UK 2019-10-22 /pmc/articles/PMC6805949/ /pubmed/31641173 http://dx.doi.org/10.1038/s41598-019-51611-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tatewaki, Yasuko
Mutoh, Tatsushi
Omodaka, Kazuko
Thyreau, Benjamin
Matsudaira, Izumi
Furukawa, Hiroaki
Yamada, Keiji
Kunitoki, Keiko
Kawashima, Ryuta
Nakazawa, Toru
Taki, Yasuyuki
Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images
title Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images
title_full Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images
title_fullStr Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images
title_full_unstemmed Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images
title_short Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images
title_sort morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional t2-weighted mr images
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805949/
https://www.ncbi.nlm.nih.gov/pubmed/31641173
http://dx.doi.org/10.1038/s41598-019-51611-0
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