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Classification of GABAergic interneurons by leading neuroscientists

There is currently no unique catalog of cortical GABAergic interneuron types. In 2013, we asked 48 leading neuroscientists to classify 320 interneurons by inspecting images of their morphology. That study was the first to quantify the degree of agreement among neuroscientists in morphology-based int...

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Autores principales: Mihaljević, Bojan, Benavides-Piccione, Ruth, Bielza, Concha, Larrañaga, Pedro, DeFelipe, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805952/
https://www.ncbi.nlm.nih.gov/pubmed/31641131
http://dx.doi.org/10.1038/s41597-019-0246-8
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author Mihaljević, Bojan
Benavides-Piccione, Ruth
Bielza, Concha
Larrañaga, Pedro
DeFelipe, Javier
author_facet Mihaljević, Bojan
Benavides-Piccione, Ruth
Bielza, Concha
Larrañaga, Pedro
DeFelipe, Javier
author_sort Mihaljević, Bojan
collection PubMed
description There is currently no unique catalog of cortical GABAergic interneuron types. In 2013, we asked 48 leading neuroscientists to classify 320 interneurons by inspecting images of their morphology. That study was the first to quantify the degree of agreement among neuroscientists in morphology-based interneuron classification, showing high agreement for the chandelier and Martinotti types, yet low agreement for most of the remaining types considered. Here we present the dataset containing the classification choices by the neuroscientists according to interneuron type as well as to five prominent morphological features. These data can be used as crisp or soft training labels for learning supervised machine learning interneuron classifiers, while further analyses can try to pinpoint anatomical characteristics that make an interneuron especially difficult or especially easy to classify.
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spelling pubmed-68059522019-10-30 Classification of GABAergic interneurons by leading neuroscientists Mihaljević, Bojan Benavides-Piccione, Ruth Bielza, Concha Larrañaga, Pedro DeFelipe, Javier Sci Data Data Descriptor There is currently no unique catalog of cortical GABAergic interneuron types. In 2013, we asked 48 leading neuroscientists to classify 320 interneurons by inspecting images of their morphology. That study was the first to quantify the degree of agreement among neuroscientists in morphology-based interneuron classification, showing high agreement for the chandelier and Martinotti types, yet low agreement for most of the remaining types considered. Here we present the dataset containing the classification choices by the neuroscientists according to interneuron type as well as to five prominent morphological features. These data can be used as crisp or soft training labels for learning supervised machine learning interneuron classifiers, while further analyses can try to pinpoint anatomical characteristics that make an interneuron especially difficult or especially easy to classify. Nature Publishing Group UK 2019-10-22 /pmc/articles/PMC6805952/ /pubmed/31641131 http://dx.doi.org/10.1038/s41597-019-0246-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files associated with this article.
spellingShingle Data Descriptor
Mihaljević, Bojan
Benavides-Piccione, Ruth
Bielza, Concha
Larrañaga, Pedro
DeFelipe, Javier
Classification of GABAergic interneurons by leading neuroscientists
title Classification of GABAergic interneurons by leading neuroscientists
title_full Classification of GABAergic interneurons by leading neuroscientists
title_fullStr Classification of GABAergic interneurons by leading neuroscientists
title_full_unstemmed Classification of GABAergic interneurons by leading neuroscientists
title_short Classification of GABAergic interneurons by leading neuroscientists
title_sort classification of gabaergic interneurons by leading neuroscientists
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805952/
https://www.ncbi.nlm.nih.gov/pubmed/31641131
http://dx.doi.org/10.1038/s41597-019-0246-8
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