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Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability

Transcranial random noise stimulation (tRNS) is a recent neuromodulation protocol. The high-frequency band (hf-tRNS) has shown to be the most effective in enhancing neural excitability. The frequency band of hf-tRNS typically spans from 100 to 640 Hz. Here we asked whether both the lower and the hig...

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Autores principales: Moret, Beatrice, Donato, Rita, Nucci, Massimo, Cona, Giorgia, Campana, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806007/
https://www.ncbi.nlm.nih.gov/pubmed/31641235
http://dx.doi.org/10.1038/s41598-019-51553-7
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author Moret, Beatrice
Donato, Rita
Nucci, Massimo
Cona, Giorgia
Campana, Gianluca
author_facet Moret, Beatrice
Donato, Rita
Nucci, Massimo
Cona, Giorgia
Campana, Gianluca
author_sort Moret, Beatrice
collection PubMed
description Transcranial random noise stimulation (tRNS) is a recent neuromodulation protocol. The high-frequency band (hf-tRNS) has shown to be the most effective in enhancing neural excitability. The frequency band of hf-tRNS typically spans from 100 to 640 Hz. Here we asked whether both the lower and the higher half of the high-frequency band are needed for increasing neural excitability. Three frequency ranges (100–400 Hz, 400–700 Hz, 100–700 Hz) and Sham conditions were delivered for 10 minutes at an intensity of 1.5 mA over the primary motor cortex (M1). Single-pulse transcranial magnetic stimulation (TMS) was delivered over the same area at baseline, 0, 10, 20, 30, 45 and 60 minutes after stimulation, while motor evoked potentials (MEPs) were recorded to evaluate changes in cortical excitability. Only the full-band condition (100–700 Hz) was able to modulate excitability by enhancing MEPs at 10 and 20 minutes after stimulation: neither the higher nor the lower sub-range of the high-frequency band significantly modulated cortical excitability. These results show that the efficacy of tRNS is strictly related to the width of the selected frequency range.
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spelling pubmed-68060072019-10-24 Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability Moret, Beatrice Donato, Rita Nucci, Massimo Cona, Giorgia Campana, Gianluca Sci Rep Article Transcranial random noise stimulation (tRNS) is a recent neuromodulation protocol. The high-frequency band (hf-tRNS) has shown to be the most effective in enhancing neural excitability. The frequency band of hf-tRNS typically spans from 100 to 640 Hz. Here we asked whether both the lower and the higher half of the high-frequency band are needed for increasing neural excitability. Three frequency ranges (100–400 Hz, 400–700 Hz, 100–700 Hz) and Sham conditions were delivered for 10 minutes at an intensity of 1.5 mA over the primary motor cortex (M1). Single-pulse transcranial magnetic stimulation (TMS) was delivered over the same area at baseline, 0, 10, 20, 30, 45 and 60 minutes after stimulation, while motor evoked potentials (MEPs) were recorded to evaluate changes in cortical excitability. Only the full-band condition (100–700 Hz) was able to modulate excitability by enhancing MEPs at 10 and 20 minutes after stimulation: neither the higher nor the lower sub-range of the high-frequency band significantly modulated cortical excitability. These results show that the efficacy of tRNS is strictly related to the width of the selected frequency range. Nature Publishing Group UK 2019-10-22 /pmc/articles/PMC6806007/ /pubmed/31641235 http://dx.doi.org/10.1038/s41598-019-51553-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moret, Beatrice
Donato, Rita
Nucci, Massimo
Cona, Giorgia
Campana, Gianluca
Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability
title Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability
title_full Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability
title_fullStr Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability
title_full_unstemmed Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability
title_short Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability
title_sort transcranial random noise stimulation (trns): a wide range of frequencies is needed for increasing cortical excitability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806007/
https://www.ncbi.nlm.nih.gov/pubmed/31641235
http://dx.doi.org/10.1038/s41598-019-51553-7
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