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Amino acid-linked platinum(II) compounds: non-canonical nucleoside preferences and influence on glycosidic bond stabilities

ABSTRACT: Nucleobases serve as ideal targets where drugs bind and exert their anticancer activities. Cisplatin (cisPt) preferentially coordinates to 2′-deoxyguanosine (dGuo) residues within DNA. The dGuo adducts that are formed alter the DNA structure, contributing to inhibition of function and ulti...

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Detalles Bibliográficos
Autores principales:	Kimutai, Bett, He, C. C., Roberts, Andrew, Jones, Marcel L., Bao, Xun, Jiang, Jun, Yang, Zhihua, Rodgers, M. T., Chow, Christine S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806012/ https://www.ncbi.nlm.nih.gov/pubmed/31359185 http://dx.doi.org/10.1007/s00775-019-01693-y

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