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Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) harbors somatic hypermutation (SHM) in the immunoglobulin heavy chain and light chain variable region genes, IGHV and IGK/LV. Recent studies have revealed that IGV SHM creates neoantigens that activate T-cell responses against B-cell lymphoma. METHOD...
Autores principales: | Xu-Monette, Zijun Y., Li, Jianyong, Xia, Yi, Crossley, Beryl, Bremel, Robert D., Miao, Yi, Xiao, Min, Snyder, Thomas, Manyam, Ganiraju C., Tan, Xiaohong, Zhang, Hongwei, Visco, Carlo, Tzankov, Alexandar, Dybkaer, Karen, Bhagat, Govind, Tam, Wayne, You, Hua, Hsi, Eric D., van Krieken, J. Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Piris, Miguel A., Winter, Jane N., Medeiros, Jeffrey T., Xu, Bing, Li, Yong, Kirsch, Ilan, Young, Ken H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806565/ https://www.ncbi.nlm.nih.gov/pubmed/31640780 http://dx.doi.org/10.1186/s40425-019-0730-x |
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