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Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance

Resistance to thyroid hormone (RTH) is a clinical disorder without specific and effective therapeutic strategy, partly due to the lack of structural mechanisms for the defective ligand binding by mutated thyroid hormone receptors (THRs). We herein uncovered the prescription drug roxadustat as a nove...

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Detalles Bibliográficos
Autores principales:	Yao, Benqiang, Wei, Yijuan, Zhang, Shuchi, Tian, Siyu, Xu, Shuangshuang, Wang, Rui, Zheng, Weili, Li, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806671/ https://www.ncbi.nlm.nih.gov/pubmed/31655060 http://dx.doi.org/10.1016/j.isci.2019.10.002

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