Comorbidities impact on the prognosis of severe acute community-acquired pneumonia

HIGHLIGHTS: Host comorbidities impact on prognosis of severe community-acquired pneumonia. Association of severity indexes, clinical and analytic parameters at admission and patient comorbidities with mortality. Characterization of severe community-acquired pneumonia patients admitted to ICU. ABSTRACT: Community-acquired pneumonia (CAP) is a frequent cause of admission to hospital worldwide with high mortality rates. Host comorbidities may be associated not just with a greater risk of developing the disease but also with worse outcomes. In this work, the evaluation of the impact of host comorbidities on the prognosis of severe CAP patients admitted to an Intensive Care Unit (ICU) was proposed. Severity indexes, some clinical and analytic parameters at admission in ICU as well as patient comorbidities were analyzed and statistically compared with mortality. In this study, although there was no clear link between comorbidities and mortality, factors such as smoking, obesity and previous renal disease impairment seem to have an impact on the prognosis of severe CAP.