Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis

NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expression in experimental models of cardiovascular di...

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Detalles Bibliográficos
Autores principales: Manea, Simona-Adriana, Vlad, Mihaela-Loredana, Fenyo, Ioana Madalina, Lazar, Alexandra-Gela, Raicu, Monica, Muresian, Horia, Simionescu, Maya, Manea, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807290/
https://www.ncbi.nlm.nih.gov/pubmed/31634818
http://dx.doi.org/10.1016/j.redox.2019.101338

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