Cytotoxic and antimicrobial potential of different varieties of ripe banana used traditionally to treat ulcers

Globally, plant as herbal medicine is used to treat different diseases. The goal of this present study was to assess the antimicrobial and cytotoxic potential of ripe banana extracts with various polarities which were grown in Oman. The powder banana samples were extracted with methanol by soaking mode. The solvent was removed by a rotary evaporator and the extract was fractionated by dissimilar polarities of solvents to give corresponding extracts. The antimicrobial and cytotoxic potential of the various polarities extracts of ripe banana were determined by modifying disc diffusion and brine shrimp lethality (BSL) bioassays. Each banana extract at different concentrations showed modest antimicrobial potential against two Gram (+) and two Gram (-) with the range of inhibition 0–13 mm. The results of cytotoxic potential revealed that the each banana extract at various applied concentrations killed the shrimp larvae. Among the extracts, the butanol and water extract gave the maximum cytotoxic potential with LC(50) value of 20.12 and 24.22 μg/ml, however, the lowest cytotoxic potential was obtained in the ethyl acetate extract with LC(50) value of 36.68 and 49.32 μg/ml. In our experimental results showed that the highest polarity banana extracts have significant antimicrobial and cytotoxic potential. In conclusion, the highest polarity extract could be a candidate for the use of antibiotics.