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K-Ras-ERK1/2 accelerates lung cancer cell development via mediating H3(K18ac) through the MDM2-GCN5-SIRT7 axis

Context: H3(K18ac) is linked to gene expression and DNA damage. Nevertheless, whether H3(K18ac) participates in regulating Ras-ERK1/2-affected lung cancer cell phenotypes remains unclear. Objective: We explored the effects of H3(K18ac) on Ras-ERK1/2-affected lung cancer cell phenotypes. Material and...

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Detalles Bibliográficos
Autores principales: Cheng, Ziming, Li, Xiufeng, Hou, Shizhen, Wu, Yubing, Sun, Yi, Liu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807650/
https://www.ncbi.nlm.nih.gov/pubmed/31613681
http://dx.doi.org/10.1080/13880209.2019.1672756

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