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Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography

PURPOSE: To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics. METHODS: This study used prospective, noncomparative case series, including 21 eyes of 21...

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Autores principales: Sekiryu, Tetsuju, Sugano, Yukinori, Ojima, Akira, Mori, Takafumi, Furuta, Minoru, Okamoto, Masahiro, Eifuku, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807678/
https://www.ncbi.nlm.nih.gov/pubmed/31649830
http://dx.doi.org/10.1167/tvst.8.5.31
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author Sekiryu, Tetsuju
Sugano, Yukinori
Ojima, Akira
Mori, Takafumi
Furuta, Minoru
Okamoto, Masahiro
Eifuku, Satoshi
author_facet Sekiryu, Tetsuju
Sugano, Yukinori
Ojima, Akira
Mori, Takafumi
Furuta, Minoru
Okamoto, Masahiro
Eifuku, Satoshi
author_sort Sekiryu, Tetsuju
collection PubMed
description PURPOSE: To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics. METHODS: This study used prospective, noncomparative case series, including 21 eyes of 21 healthy individuals. The 6 × 6-mm macular area was imaged repeatedly to obtain two cube image sets. Images from structural OCT (OCT-S) and OCT angiography (OCT-A) were exported. After vessel-like structures segmentation from the inverted black and white OCT-S images and the OCT-A images, both types of images were reconstructed in a 3D model. The volumes of the outer choroid and the choroidal vessels were measured after thresholding. The similarities of the segmented choroidal vessels (between OCT-S and OCT-A) and between repeatedly acquired images were measured. RESULTS: Mean vessel volume was 2.227 mm(3) (29% of the outer choroidal volume) in OCT-S and 0.848 (11%) in OCT-A when measured after removal of the choriocapillaris equivalent volume. Three percent of the vessel volume in OCT-S and 8.4% of that in OCT-A overlapped. The Dice similarity coefficient of vessel volumes in repeated images from the same individual was 0.863 in OCT-S and 0.485 in OCT-A. The ratio of vessel volume to the outer choroidal volume was invariant in OCT-S but increased in OCT-A in the eyes with long axial length. CONCLUSIONS: Hybrid 3D vascular models of the choroidal vasculature were reconstructed from OCT-S and OCT-A. The new models should prove useful for volumetric analysis of the choroid. TRANSLATIONAL RELEVANCE: Hybrid 3D models of the choroidal vasculature enable volumetric analysis and facilitate morphologic evaluation.
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spelling pubmed-68076782019-10-24 Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography Sekiryu, Tetsuju Sugano, Yukinori Ojima, Akira Mori, Takafumi Furuta, Minoru Okamoto, Masahiro Eifuku, Satoshi Transl Vis Sci Technol Articles PURPOSE: To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics. METHODS: This study used prospective, noncomparative case series, including 21 eyes of 21 healthy individuals. The 6 × 6-mm macular area was imaged repeatedly to obtain two cube image sets. Images from structural OCT (OCT-S) and OCT angiography (OCT-A) were exported. After vessel-like structures segmentation from the inverted black and white OCT-S images and the OCT-A images, both types of images were reconstructed in a 3D model. The volumes of the outer choroid and the choroidal vessels were measured after thresholding. The similarities of the segmented choroidal vessels (between OCT-S and OCT-A) and between repeatedly acquired images were measured. RESULTS: Mean vessel volume was 2.227 mm(3) (29% of the outer choroidal volume) in OCT-S and 0.848 (11%) in OCT-A when measured after removal of the choriocapillaris equivalent volume. Three percent of the vessel volume in OCT-S and 8.4% of that in OCT-A overlapped. The Dice similarity coefficient of vessel volumes in repeated images from the same individual was 0.863 in OCT-S and 0.485 in OCT-A. The ratio of vessel volume to the outer choroidal volume was invariant in OCT-S but increased in OCT-A in the eyes with long axial length. CONCLUSIONS: Hybrid 3D vascular models of the choroidal vasculature were reconstructed from OCT-S and OCT-A. The new models should prove useful for volumetric analysis of the choroid. TRANSLATIONAL RELEVANCE: Hybrid 3D models of the choroidal vasculature enable volumetric analysis and facilitate morphologic evaluation. The Association for Research in Vision and Ophthalmology 2019-10-22 /pmc/articles/PMC6807678/ /pubmed/31649830 http://dx.doi.org/10.1167/tvst.8.5.31 Text en Copyright 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Sekiryu, Tetsuju
Sugano, Yukinori
Ojima, Akira
Mori, Takafumi
Furuta, Minoru
Okamoto, Masahiro
Eifuku, Satoshi
Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography
title Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography
title_full Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography
title_fullStr Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography
title_full_unstemmed Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography
title_short Hybrid Three-Dimensional Visualization of Choroidal Vasculature Imaged by Swept-Source Optical Coherence Tomography
title_sort hybrid three-dimensional visualization of choroidal vasculature imaged by swept-source optical coherence tomography
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807678/
https://www.ncbi.nlm.nih.gov/pubmed/31649830
http://dx.doi.org/10.1167/tvst.8.5.31
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