Cargando…

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

PURPOSE: Retinitis pigmentosa (RP), a retinal photoreceptor degeneration, typically affects rod function and subsequently cones. Activation of sigma 1 receptor (Sig1R) has been shown to preserve cone function through 6 weeks in the rd10 mouse model of RP, when mice were treated systemically with the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jing, Saul, Alan, Smith, Sylvia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808049/ https://www.ncbi.nlm.nih.gov/pubmed/31639826 http://dx.doi.org/10.1167/iovs.19-27709

Ejemplares similares

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa
por: Wang, Jing, et al.
Publicado: (2017)

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa
por: Xiao, Haiyan, et al.
Publicado: (2020)

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2(Akita/+) Murine Model of Diabetic Retinopathy
por: Wang, Jing, et al.
Publicado: (2016)

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection
por: Zhao, Jing, et al.
Publicado: (2022)

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa
por: Nakamura, Paul A., et al.
Publicado: (2016)

Expression Profiling Analysis Reveals Key MicroRNA–mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa
por: Anasagasti, Ander, et al.
Publicado: (2018)

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa
por: Sudharsan, Raghavi, et al.
Publicado: (2017)

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity
por: Zhao, Jing, et al.
Publicado: (2021)

Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP
por: Wang, Jing, et al.
Publicado: (2020)

Retinal Cone Mosaic in sws1-Mutant Medaka (Oryzias latipes), A Teleost
por: Matsuo, Megumi, et al.
Publicado: (2022)

Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes
por: Fu, Jinling, et al.
Publicado: (2018)

The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival
por: Lessieur, Emma M., et al.
Publicado: (2017)

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice
por: Lian, Lili, et al.
Publicado: (2022)

Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration
por: Moisseiev, Elad, et al.
Publicado: (2016)

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity
por: Shaw, Lynn Calvin, et al.
Publicado: (2018)

Analysis of imaging biomarkers and retinal nerve fiber layer thickness in RPGR-associated retinitis pigmentosa
por: Birtel, Theresa H., et al.
Publicado: (2021)

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats
por: McLelland, Bryce T., et al.
Publicado: (2018)

Postponed care due to COVID-19 lockdown impact on visual acuity of retinal vein occlusion patients: a large cohort
por: Cohen, Ram, et al.
Publicado: (2022)

Abnormal Cone and Rod Photoreceptor Morphogenesis in gdf6a Mutant Zebrafish
por: Nadolski, Nathan J., et al.
Publicado: (2020)

Relationship between retinal fluid and visual acuity in patients with exudative age-related macular degeneration treated with intravitreal aflibercept using a treat-and-extend regimen: subgroup and post-hoc analyses from the ALTAIR study
por: Ohji, Masahito, et al.
Publicado: (2021)

Attenuation of Microglial Activation and Pyroptosis by Inhibition of P2X7 Pathway Promotes Photoreceptor Survival in Experimental Retinal Detachment
por: Cao, Manjing, et al.
Publicado: (2023)

BBSome Component BBS5 Is Required for Cone Photoreceptor Protein Trafficking and Outer Segment Maintenance
por: Bales, Katie L., et al.
Publicado: (2020)

Low-Intensity Exercise in Mice Is Sufficient to Protect Retinal Function During Light-Induced Retinal Degeneration
por: Mees, Lukas M., et al.
Publicado: (2019)

Switching anti-VEGF agent for wet AMD: evaluation of impact on visual acuity, treatment frequency and retinal morphology in a real-world clinical setting
por: Granstam, Elisabet, et al.
Publicado: (2021)

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
por: Rochfort, Keith D., et al.
Publicado: (2019)

Granulin 1 Promotes Retinal Regeneration in Zebrafish
por: Tsuruma, Kazuhiro, et al.
Publicado: (2018)

Role of Translational Attenuation in Inherited Retinal Degeneration
por: Starr, Christopher R., et al.
Publicado: (2019)

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity
por: Han, Xiaokun, et al.
Publicado: (2019)

Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice
por: Shu, Wanting, et al.
Publicado: (2019)

Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa
por: Zabek, Olga, et al.
Publicado: (2020)

Anatomical and Gene Expression Changes in the Retinal Pigmented Epithelium Atrophy 1 (rpea1) Mouse: A Potential Model of Serous Retinal Detachment
por: Luna, Gabriel, et al.
Publicado: (2016)

Correlation between change in central subfield thickness and change in visual acuity in macular edema due to retinal vein occlusion: post hoc analysis of COPERNICUS, GALILEO, and VIBRANT
por: Gu, Sophie Z., et al.
Publicado: (2022)

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model
por: Wu, You-Ren, et al.
Publicado: (2021)

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2016)

Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration
por: Chakraborty, Dibyendu, et al.
Publicado: (2016)

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury
por: Liu, Wei, et al.
Publicado: (2019)

Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation
por: Baumann, Bailey, et al.
Publicado: (2017)

Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy
por: Gersztenkorn, David, et al.
Publicado: (2016)

Nestin Regulates Müller Glia Proliferation After Retinal Injury
por: Motoyoshi, Aya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gi9qiaqkjdfrr4nvs8mq849d13