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Identification of neoantigens derived from alternative splicing and RNA modification
The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korea Genome Organization
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808645/ https://www.ncbi.nlm.nih.gov/pubmed/31610619 http://dx.doi.org/10.5808/GI.2019.17.3.e23 |
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author | Park, Jiyeon Chung, Yeun-Jun |
author_facet | Park, Jiyeon Chung, Yeun-Jun |
author_sort | Park, Jiyeon |
collection | PubMed |
description | The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data. |
format | Online Article Text |
id | pubmed-6808645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korea Genome Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-68086452019-10-24 Identification of neoantigens derived from alternative splicing and RNA modification Park, Jiyeon Chung, Yeun-Jun Genomics Inform Review Article The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data. Korea Genome Organization 2019-08-22 /pmc/articles/PMC6808645/ /pubmed/31610619 http://dx.doi.org/10.5808/GI.2019.17.3.e23 Text en (c) 2019, Korea Genome Organization (CC) This is an open-access article distributed under the terms of the Creative Commons Attribution license(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Park, Jiyeon Chung, Yeun-Jun Identification of neoantigens derived from alternative splicing and RNA modification |
title | Identification of neoantigens derived from alternative splicing and RNA modification |
title_full | Identification of neoantigens derived from alternative splicing and RNA modification |
title_fullStr | Identification of neoantigens derived from alternative splicing and RNA modification |
title_full_unstemmed | Identification of neoantigens derived from alternative splicing and RNA modification |
title_short | Identification of neoantigens derived from alternative splicing and RNA modification |
title_sort | identification of neoantigens derived from alternative splicing and rna modification |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808645/ https://www.ncbi.nlm.nih.gov/pubmed/31610619 http://dx.doi.org/10.5808/GI.2019.17.3.e23 |
work_keys_str_mv | AT parkjiyeon identificationofneoantigensderivedfromalternativesplicingandrnamodification AT chungyeunjun identificationofneoantigensderivedfromalternativesplicingandrnamodification |