1502. Risk Factors Associated to Aeromonas spp. Infection and Outcome at a Third-level Care Hospital in Mexico

BACKGROUND: Information regarding infections caused by Aeromonas spp. is limited. The aim of this study was to describe the clinical and epidemiologic characteristics of infections by Aeromonas spp. during a 7-year period at a tertiary care hospital in Mexico. METHODS: We analyzed a retrospective cohort of adults with Aeromonas spp. clinical isolates, between January 1, 2010 and August 31, 2017 from the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. We analyzed demographic, clinical, microbial characteristics and antimicrobial susceptibility test. Risk factors for bacteremia and mortality were identified with logistic regression; adjustment for possible confounder factors was carried out. Data were analyzed with IBM SPSS Statistics version 21. Statistical significance was defined as the value for P < 0.05. RESULTS: We identified 387 patients with an infection by Aeromonas spp.; the median age was 55 years and 52% were women. 94 (24.3%) patients had an autoimmune disease; 74 (19.1%) had a solid tumor (ST); 51 (13.2%) had chronic kidney disease (CKD); 43 (11.1%) had chronic liver disease (CLD); 37 (9.6%) had a hematologic malignancy (HM); 23 (5.9%) were solid-organ recipients and 20 (5.2%) HIV infected. 41.6% (n = 161) of the infections were healthcare related. Stools were the most frequent isolation site (n = 299, 77%), followed by blood cultures (n = 29, 7.4%) and abscess (n = 19, 4.9%). The most common species was A. veronii. Aminoglycosides, quinolones, carbapenems, and trimethoprim/sulfamethoxazole were the most active antibiotics in vitro. The variables associated with bacteremia were CLD OR 5.647; diabetes OR 2.376 and nosocomial acquisition OR 4.08. 30-day mortality was 5.7%, while global mortality was 10.3%. Mortality was associated with sex (male) OR 1.753; HM OR 2.741; ST OR 2.576; polymicrobial infection OR 2.445; ICU admission OR 5.175 and bacteremia OR 3.881. CONCLUSION: Infections by Aeromonas spp. have increased and have a greater incidence among individuals with chronic diseases and immunosuppressive states in this setting. Mortality described in this cohort was minor than previously stated by other series. [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures.