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971. The Role of Inflammation and Innate Effectors in Passive Immunization for Acinetobacter baumannii Infections

BACKGROUND: We have previously demonstrated that A. baumannii virulence is driven by avoidance of innate effector clearance, resulting in LPS-TLR4 triggering of excess inflammation in the host. We also raised a monoclonal antibody (MAb) that improved survival of mice lethally infected with A. bauman...

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Detalles Bibliográficos
Autores principales: Nielsen, Travis B, Yan, Jun, Luna, Brian M, Talyansky, Yuli, Bonomo, Robert A, Spellberg, Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808996/
http://dx.doi.org/10.1093/ofid/ofz359.073