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974. PD-1 Immune Checkpoint Blockade Improves Survival and Promotes Fungal Clearance in an Immunosuppressed Murine Invasive Pulmonary Aspergillosis (IPA) Model

BACKGROUND: Checkpoint blockade (CPB) has brought a revolution in modern oncology and may offer new strategies for antifungal immunotherapy. In vitro studies have demonstrated that blockade of the PD-1/PDL-1 interaction increased IFN-γ secretion in response to Aspergillus antigens, suggesting a pote...

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Detalles Bibliográficos
Autores principales:	Wurster, Sebastian, Robinson, Prema, Albert, Nathaniel D, Lionakis, Michail S, Kontoyiannis, Dimitrios P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809042/ http://dx.doi.org/10.1093/ofid/ofz359.076

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